Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (Me-Can): analysis of six prospective cohorts.

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Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (Me-Can) : analysis of six prospective cohorts.

Stocks, Tanja, 1977- (författare): Umeå University,Umeå universitet,Urologi och andrologi

Rapp, Kilian (författare): Ulm University, Germany

Bjorge, Tone (författare): University of Bergen

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Manjer, Jonas (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Malmö University Hospital

Ulmer, Hanno (författare): Innsbruck Medical University

Selmer, Randi (författare): Norwegian Institute of Public Health, Norway

Lukanova, Annekatrin (författare): German Cancer Research Center, Germany

Johansen, Dorthe (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Malmö University Hospital

Concin, Hans (författare): Agency for Preventive and Social Medicine, Austria

Tretli, Steinar (författare): The Cancer Registry of Norway, Norway

Hallmans, Göran (författare): Umeå universitet,Näringsforskning

Jonsson, Håkan (författare): Umeå universitet,Onkologi

Stattin, Pär (författare): Umeå universitet,Urologi och andrologi

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(creator_code:org_t)

2009-12-22
2009
Engelska.
Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 6:12, s. e1000201-

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BackgroundProspective studies have indicated that elevated blood glucose levels may increase the risk of cancer, but the strength of the association is unclear. We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts. Methods and Findings The Metabolic syndrome and Cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included 274,126 men and 275,818 women. Mean age at baseline was 44.8 years and mean follow-up time was 10.4 years. Excluding the first year of follow-up, 18,621 men and 11,664 women were diagnosed with cancer, and 6,973 men and 3,088 women died of cancer. We used Cox regression models to calculate relative risk (RR) for glucose levels, and included adjustment for body mass index (BMI) and smoking status in the analyses. RRs were corrected for regression dilution ratio of glucose. RR (95% confidence interval) per 1 mmol/l increment of glucose for overall incident cancer was 1.05 (1.01-1.10) in men and 1.11 (1.05-1.16) in women, and corresponding RRs for fatal cancer were 1.15 (1.07-1.22) and 1.21 (1.11-1.33), respectively. Significant increases in risk among men were found for incident and fatal cancer of the liver, gallbladder and respiratory tract, for incident thyroid cancer and multiple myeloma, and for fatal rectal cancer. In women, significant associations were found for incident and fatal cancer of the pancreas, for incident urinary bladder cancer, and for fatal cancer of the uterine corpus, cervix uteri, and stomach.ConclusionsData from our study indicate that abnormal glucose metabolism, independently of BMI, is associated with an increased risk of cancer overall and at several cancer sites. Our data showed stronger associations among women than among men, and for fatal cancer compared to incident cancer.

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Av författaren/redakt...: Stocks, Tanja, 1 ...; Rapp, Kilian; Bjorge, Tone; Manjer, Jonas; Ulmer, Hanno; Selmer, Randi; visa fler...; Lukanova, Anneka ...; Johansen, Dorthe; Concin, Hans; Tretli, Steinar; Hallmans, Göran; Jonsson, Håkan; Stattin, Pär; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

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Av lärosätet: Umeå universitet; Lunds universitet

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Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (Me-Can) : analysis of six prospective cohorts.

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