WFRF:(Selmeryd Jonas)
Search: WFRF:(Selmeryd Jonas) > (2017) > Long-term prognosti...
- 1 of 1
- Previous record
- Next record
- To hitlist
Long-term prognostic impact of left atrial volumes and emptying fraction in a community-based cohort
-
- Hedberg, Pär (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
-
- Selmeryd, Jonas (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
-
- Leppert, Jerzy (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
- show more...
- show less...
- (creator_code:org_t)
- 2016-11-09
- 2017
- English.
- In: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:9, s. 687-693
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Objective: We hypothesised that left atrial emptying fraction (LAEF) would predict long-term cardiovascular outcome in the general population and better so than left atrial (LA) volumes.Methods: A community-based sample (n=740) in sinus rhythm prospectively underwent clinical evaluation, echocardiography and blood analyses including N terminal pro B-type natriuretic peptide (NTproBNP). The LA maximum (LAVmax) and minimum volumes (LAVmin) were indexed to body surface area (LAVImax and LAVImin, respectively). LAEF was calculated as LAVmaxLAVmin divided by LAVmax. The participants were followed for a median of 4.9 years regarding incident cardiovascular events (cardiovascular death or hospitalisation because of myocardial infarction, heart failure or stroke). Cox regression models were used to evaluate the associations of LA volumes and LAEF with the outcome.Results: In a multivariable beta regression model, including clinical and echocardiographic baseline characteristics, higher plasma levels of NTproBNP, higher E/e' and left ventricular systolic dysfunction remained as independent determinants of a lower LAEF. After adjustment for baseline characteristics, including NTproBNP levels, LAEF (HR for 1 SD decrease 1.33, 95% CI 1.04 to 1.70, p=0.022), but not LAVImax (HR for 1 SD increase 0.88, 95% CI 0.70 to 1.10, p=0.25) or LAVImin (HR for 1 SD increase 1.02, 95% CI 0.83 to 1.27, p=0.83) remained independently associated with outcome.Conclusions: In this community-based cohort, LAEF was a powerful predictor of incident cardiovascular events and its predictive ability was stronger than for LA volumes. Our findings suggest that LA dysfunction may represent a more advanced state of LA remodelling than LA enlargement.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- ventricular systolic function
- preserved ejection fraction
- heart-failure
- reservoir function
- magnetic-resonance
- minimum volume
- maximum
- fibrillation
- association
- population
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Hedberg, Pär
- Selmeryd, Jonas
- Leppert, Jerzy
- Henriksen, Egil
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Heart
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
