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WFRF:(Shahba Faezeh)
 

Sökning: WFRF:(Shahba Faezeh) > Interleukin-1 recep...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003657naa a2200421 4500
001oai:lup.lub.lu.se:02b89c8e-5b01-4d18-b026-6accc9af219f
003SwePub
008231218s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/02b89c8e-5b01-4d18-b026-6accc9af219f2 URI
0247 a https://doi.org/10.1016/j.critrevonc.2023.1042002 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Zarezadeh Mehrabadi, Aliu Iran University of Medical Sciences4 aut
2451 0a Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies
264 1c 2024
520 a IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma. Additionally, IL-1RAP interacts with solute carrier family 3 member 2 (SLC3A2) and thereby increasing the resistance to anoikis and metastasis in Ewing sarcoma. This review summarizes the role of IL-1RAP in different types of cancers and discusses its targeting as a novel therapeutic approach for malignancies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Cancer immunotherapy
653 a Chronic inflammation
653 a IL-1 receptor accessory protein
653 a Interleukin-1
7001 a Shahba, Faezehu Iran University of Medical Sciences4 aut
7001 a Khorramdelazad, Hosseinu Rafsanjan University of Medical Sciences4 aut
7001 a Aghamohammadi, Nazaninu Iran University of Medical Sciences4 aut
7001 a Karimi, Miladu Iran University of Medical Sciences4 aut
7001 a Bagherzadeh, Kowsaru Iran University of Medical Sciences4 aut
7001 a Khoshmirsafa, Majidu Iran University of Medical Sciences4 aut
7001 a Massoumi, Raminu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Tumor Pathology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)expp-rma
7001 a Falak, Rezau Iran University of Medical Sciences4 aut
7102 a Iran University of Medical Sciencesb Rafsanjan University of Medical Sciences4 org
7730 t Critical Reviews in Oncology/Hematologyg 193q 193x 1040-8428
8564 u http://dx.doi.org/10.1016/j.critrevonc.2023.104200y FULLTEXT
8564 8u https://lup.lub.lu.se/record/02b89c8e-5b01-4d18-b026-6accc9af219f
8564 8u https://doi.org/10.1016/j.critrevonc.2023.104200

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