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Sökning: WFRF:(Shamlaye Conrad F.) > (2015) > Genetic variation i...

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FältnamnIndikatorerMetadata
00005316naa a2200565 4500
001oai:lup.lub.lu.se:4ae15766-1d41-4126-90cf-ddfee80e3cfa
003SwePub
008160401s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132481081
0247 a https://lup.lub.lu.se/record/81491442 URI
0247 a https://doi.org/10.1016/j.plefa.2015.08.0042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1324810812 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Yeates, Alison J4 aut
2451 0a Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.
264 1b Elsevier BV,c 2015
338 a electronic2 rdacarrier
520 a Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variability in FADS1 and FADS2 genes to maternal LC-PUFA status and infant neurodevelopment in populations with high fish intakes. The Nutrition Cohorts 1 (NC1) and 2 (NC2) are longitudinal observational mother-child cohorts in the Republic of Seychelles. Maternal serum LC-PUFA was measured at 28 weeks gestation and genotyping for rs174537 (FADS1), rs174561 (FADS1), rs3834458 (FADS1-FADS2) and rs174575 (FADS2) was performed in both cohorts. The children completed the Bayley Scales of Infant Development II (BSID-II) at 30 months in NC1 and at 20 months in NC2. Complete data were available for 221 and 1310 mothers from NC1 and NC2 respectively. With increasing number of rs3834458 minor alleles, maternal concentrations of AA were significantly decreased (NC1 p=0.004; NC2 p<0.001) and precursor:product ratios for linoleic acid (LA) (18:2n-6)-to-AA (NC1 p<0.001; NC2 p<0.001) and α-linolenic acid (ALA) (18:3n-3)-to-DHA were increased (NC2 p=0.028). There were no significant associations between maternal FADS genotype and BSID-II scores in either cohort. A trend for improved PDI was found among infants born to mothers with the minor rs3834458 allele.In these high fish-eating cohorts, genetic variability in FADS genes was associated with maternal AA status measured in serum and a subtle association of the FADS genotype was found with neurodevelopment.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
7001 a Love, Tanzy M4 aut
7001 a Engström, Karinu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-ksk
7001 a Mulhern, Maria S4 aut
7001 a McSorley, Emeir M4 aut
7001 a Grzesik, Katherine4 aut
7001 a Alhamdow, Aymanu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-aa10
7001 a Wahlberg, Karin Eu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)immu-kwa
7001 a Thurston, Sally W4 aut
7001 a Davidson, Philip W4 aut
7001 a van Wijngaarden, Edwin4 aut
7001 a Watson, Gene E4 aut
7001 a Shamlaye, Conrad F4 aut
7001 a Myers, G J4 aut
7001 a Strain, J J4 aut
7001 a Broberg, Karin4 aut
7102 a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org
7730 t Prostaglandins, Leukotrienes and Essential Fatty Acidsd : Elsevier BVg 102-103, s. 13-20q 102-103<13-20x 0952-3278x 1532-2823
8564 u https://portal.research.lu.se/files/1564237/8862712.pdfx primaryx freey FULLTEXT
8564 u http://www.ncbi.nlm.nih.gov/pubmed/26474818?dopt=Abstractx freey FULLTEXT
8564 u http://dx.doi.org/10.1016/j.plefa.2015.08.004x freey FULLTEXT
8564 u http://www.plefa.com/article/S0952327815001556/pdf
8564 8u https://lup.lub.lu.se/record/8149144
8564 8u https://doi.org/10.1016/j.plefa.2015.08.004
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132481081

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