Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study

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Lifestyle and metabolic factors for nonalcoholic fatty liver disease : Mendelian randomization study

Yuan, Shuai (author): Karolinska Institutet

Chen, Jie (author): Zhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.

Li, Xue (author): Zhejiang Univ, Sch Publ Hlth, Sch Med, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Peoples R China.;Univ Edinburgh, Ctr Global Hlth, Usher Inst, Edinburgh, Midlothian, Scotland.

Fan, Rongrong (author): Karolinska Institutet

Arsenault, Benoit (author): Ctr Rech Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada.;Univ Laval, Fac Med, Dept Med, Quebec City, PQ, Canada.

Gill, Dipender (author): Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;St Georges Univ London, Inst Infect & Immun, Clin Pharmacol & Therapeut Sect, London, England.;St Georges Univ Hosp NHS Fdn Trust, Pharm & Med Directorate, Clin Pharmacol Grp, London, England.;Novo Nordisk Res Ctr Oxford, Old Rd Campus, Oxford, England.

Giovannucci, Edward L. (author): Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.

Zheng, Ju-Sheng (author): Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pr, Hangzhou, Peoples R China.

Larsson, Susanna C. (author): Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Nobelsvag 13, S-17177 Stockholm, Sweden.

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Karolinska Institutet Zhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou, Peoples R China;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China. (creator_code:org_t)

2022-04-30
2022
English.
In: European Journal of Epidemiology. - : Springer. - 0393-2990 .- 1573-7284. ; 37:7, s. 723-733

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

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The risk factors for nonalcoholic fatty liver disease (NAFLD) have not been clearly identified. We conducted a Mendelian randomization (MR) study to explore this. Independent genetic variants strongly associated with 5 lifestyle and 9 metabolic factors were selected as instrumental variables from corresponding genome-wide association studies (GWASs). Summary-level data for NAFLD were obtained from a GWAS meta-analysis of 8434 cases and 770,180 non-cases (discovery dataset) and another GWAS meta-analysis of 1483 cases and 17,781 non-cases (replication dataset). Univariable and multivariable MR analyses were performed. There were associations with NAFLD for lifetime smoking index (odds ratio (OR) 1.59, 95% confidence interval (CI) 1.31-1.93 per SD-increase), body mass index (BMI, OR 1.33, 95% CI 1.23-1.43 per SD-increase), waist circumference (OR 1.82; 95% CI 1.48-2.24 per SD-increase), type 2 diabetes (OR 1.21, 95% CI 1.15-1.27 per unit increase in log-transformed odds), systolic blood pressure (OR 1.17; 95% CI 1.07-1.26 per 10 mmHg increase), high-density lipoprotein cholesterol (OR 0.84, 95% CI 0.77-0.90 per SD-increase), and triglycerides (OR 1.23, 95% CI 1.15-1.33 per SD-increase). The associations for type 2 diabetes, systolic blood pressure, triglycerides, but not for high-density lipoprotein cholesterol remained strong after adjusting for genetically-predicted BMI. Genetic liability to type 2 diabetes mediated 51.4% (95% CI 13.4-89.3%) of the BMI-effects on NAFLD risk. There were suggestive inverse associations of genetically-predicted alcohol, coffee, and caffeine consumption, and vigorous physical activity with NAFLD risk. This study identified several lifestyle and metabolic factors that may be causally implicated in NAFLD.

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By the author/editor: Yuan, Shuai; Chen, Jie; Li, Xue; Fan, Rongrong; Arsenault, Benoi ...; Gill, Dipender; show more...; Giovannucci, Edw ...; Zheng, Ju-Sheng; Larsson, Susanna ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: European Journal ...

By the university: Uppsala University; Karolinska Institutet

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Lifestyle and metabolic factors for nonalcoholic fatty liver disease : Mendelian randomization study

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