WFRF:(Shilkova O)
Sökning: WFRF:(Shilkova O) > (2021) > Orphan GPR116 media...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03475naa a2200697 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:146789714 | |
| 003 | SwePub | |
| 008 | 240913s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1467897142 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-021-22579-12 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Georgiadi, A4 aut |
| 245 | 1 0 | a Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue |
| 264 | c 2021-05-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a The proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is a hallmark of severe metabolic dysfunction in obesity and diabetes. Here, we show that the FNDC4-GPR116, liver-white adipose tissue endocrine axis controls glucose homeostasis. We found that the liver primarily controlled the circulating levels of soluble FNDC4 (sFNDC4) and lowering of the hepatokine FNDC4 led to prediabetes in mice. Further, we identified the orphan adhesion GPCR GPR116 as a receptor of sFNDC4 in the white adipose tissue. Upon direct and high affinity binding of sFNDC4 to GPR116, sFNDC4 promoted insulin signaling and insulin-mediated glucose uptake in white adipocytes. Indeed, supplementation with FcsFNDC4 in prediabetic mice improved glucose tolerance and inflammatory markers in a white-adipocyte selective and GPR116-dependent manner. Of note, the sFNDC4-GPR116, liver-adipose tissue axis was dampened in (pre) diabetic human patients. Thus our findings will now allow for harnessing this endocrine circuit for alternative therapeutic strategies in obesity-related pre-diabetes. | |
| 700 | 1 | a Lopez-Salazar, V4 aut |
| 700 | 1 | a El-Merahbi, R4 aut |
| 700 | 1 | a Karikari, RA4 aut |
| 700 | 1 | a Ma, XC4 aut |
| 700 | 1 | a Mouraeo, A4 aut |
| 700 | 1 | a Klepac, K4 aut |
| 700 | 1 | a Buehler, L4 aut |
| 700 | 1 | a Alfaro, AJ4 aut |
| 700 | 1 | a Kaczmarek, I4 aut |
| 700 | 1 | a Linford, A4 aut |
| 700 | 1 | a Bosma, M4 aut |
| 700 | 1 | a Shilkova, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Ritvos, O4 aut |
| 700 | 1 | a Nakamura, N4 aut |
| 700 | 1 | a Hirose, S4 aut |
| 700 | 1 | a Lassi, M4 aut |
| 700 | 1 | a Teperino, R4 aut |
| 700 | 1 | a Machado, J4 aut |
| 700 | 1 | a Scheideler, M4 aut |
| 700 | 1 | a Dietrich, A4 aut |
| 700 | 1 | a Geerlof, A4 aut |
| 700 | 1 | a Feuchtinger, A4 aut |
| 700 | 1 | a Blutke, A4 aut |
| 700 | 1 | a Fischer, K4 aut |
| 700 | 1 | a Mueller, TD4 aut |
| 700 | 1 | a Kessler, K4 aut |
| 700 | 1 | a Schoeneberg, T4 aut |
| 700 | 1 | a Thor, D4 aut |
| 700 | 1 | a Hornemann, S4 aut |
| 700 | 1 | a Kruse, M4 aut |
| 700 | 1 | a Nawroth, P4 aut |
| 700 | 1 | a Pivovarova-Ramich, O4 aut |
| 700 | 1 | a Pfeiffer, AFH4 aut |
| 700 | 1 | a Sattler, M4 aut |
| 700 | 1 | a Blueher, M4 aut |
| 700 | 1 | a Herzig, S4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 12:1, s. 2999-q 12:1<2999-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-021-22579-1.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146789714 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-021-22579-1 |
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- Georgiadi, A
- Lopez-Salazar, V
- El-Merahbi, R
- Karikari, RA
- Ma, XC
- Mouraeo, A
- visa fler...
- Klepac, K
- Buehler, L
- Alfaro, AJ
- Kaczmarek, I
- Linford, A
- Bosma, M
- Shilkova, O
- Ritvos, O
- Nakamura, N
- Hirose, S
- Lassi, M
- Teperino, R
- Machado, J
- Scheideler, M
- Dietrich, A
- Geerlof, A
- Feuchtinger, A
- Blutke, A
- Fischer, K
- Mueller, TD
- Kessler, K
- Schoeneberg, T
- Thor, D
- Hornemann, S
- Kruse, M
- Nawroth, P
- Pivovarova-Ramic ...
- Pfeiffer, AFH
- Sattler, M
- Blueher, M
- Herzig, S
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