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Association of soci...
Association of social isolation and loneliness with risk of incident hospital-treated infections : an analysis of data from the UK Biobank and Finnish Health and Social Support studies
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- Elovainio, Marko (författare)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland ; Finnish Institute for Health and Welfare, Helsinki, Finland
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- Komulainen, Kaisla (författare)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland ; Finnish Institute for Health and Welfare, Helsinki, Finland
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- Sipilä, Pyry N. (författare)
- Clinicum, Faculty of Medicine, University of Helsinki, Finland
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- Pulkki-Råback, Laura (författare)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
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- Cachón Alonso, Laura (författare)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
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- Pentti, Jaana (författare)
- Clinicum, Faculty of Medicine, University of Helsinki, Finland
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- Nyberg, Solja T. (författare)
- Clinicum, Faculty of Medicine, University of Helsinki, Finland
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- Suominen, Sakari (författare)
- Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Public Health, University of Turku, Finland ; Centre of Population Health Research, Turku University Hospital, Finland,Medborgarcentrerad hälsa MeCH, Research on Citizen Centered Health, University of Skövde (Reacch US)
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- Vahtera, Jussi (författare)
- Department of Public Health, University of Turku, Finland ; Centre of Population Health Research, Turku University Hospital, Finland
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- Lipsanen, Jari (författare)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
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- Batty, G. David (författare)
- Department of Epidemiology and Public Health, University College London, United Kingdom
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- Hakulinen, Christian (författare)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland ; Finnish Institute for Health and Welfare, Helsinki, Finland
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- Kivimäki, Mika (författare)
- Clinicum, Faculty of Medicine, University of Helsinki, Finland ; Department of Mental Health of Older People, Faculty of Brain Sciences, University College London, United Kingdom
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: The Lancet Public Health. - : Elsevier. - 2468-2667. ; 8:2, s. e109-e118
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Although loneliness and social isolation have been linked to an increased risk of non-communicable diseases such as cardiovascular disease and dementia, their association with the risk of severe infection is uncertain. We aimed to examine the associations between loneliness and social isolation and the risk of hospital-treated infections using data from two independent cohort studies. Methods: We assessed the association between loneliness and social isolation and incident hospital-treated infections using data for participants from the UK Biobank study aged 38–73 years at baseline and participants from the nationwide population-based Finnish Health and Social Support (HeSSup) study aged 20–54 years at baseline. For inclusion in the study, participants had to be linked to national health registries, have no history of hospital-treated infections at or before baseline, and have complete data on loneliness or social isolation. Participants with missing data on hospital-treated infections, loneliness, and social isolation were excluded from both cohorts. The outcome was defined as a hospital admission with a primary diagnosis of infection, ascertained via linkage to electronic health records. Findings: After exclusion of 8·6 million participants for not responding or not providing appropriate consent, the UK Biobank cohort consisted of 456 905 participants (249 586 women and 207 319 men). 26 860 (6·2%) of 436 001 participants with available data were reported as being lonely and 40 428 (9·0%) of 448 114 participants with available data were socially isolated. During a median 8·9 years (IQR 8·0–9·6) of follow-up, 51 361 participants were admitted to hospital due to an infectious disease. After adjustment for age, sex, demographic and lifestyle factors, and morbidities, loneliness was associated with an increased risk of a hospital-treated infection (hazard ratio [HR] 1·12 [95% CI 1·07–1·16]), whereas social isolation was not (HR 1·01 [95% CI 0·97–1·04]). Of 64 797 individuals in the HeSSup cohort, 18 468 (11 367 women and 7101 men) were eligible for inclusion. 4466 (24·4%) of 18 296 were lonely and 1776 (9·7%) of 18 376 socially isolated. During a median follow-up of 10·0 years (IQR 10·0–10·1), 814 (4·4%) participants were admitted to hospital for an infectious disease. The HRs for the HeSSup study replicated those in the UK Biobank (multivariable-adjusted HR for loneliness 1·32 [95% CI 1·06–1·64]; 1·08 [0·87–1·35] for social isolation). Interpretation: Loneliness might increase susceptibility to severe infections, although the magnitude of this effect appears modest and residual confounding cannot be excluded. Interventional studies are required before policy recommendations can advance. Funding: Academy of Finland, the UK Medical Research Council, and Wellcome Trust UK.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Biological Specimen Banks
- Communicable Diseases
- Female
- Finland
- Humans
- Loneliness
- Male
- Social Support
- United Kingdom
- biobank
- communicable disease
- epidemiology
- human
- Research on Citizen Centered Health, University of Skövde (Reacch US)
- Medborgarcentrerad hälsa (Mech)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Elovainio, Marko
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Komulainen, Kais ...
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Sipilä, Pyry N.
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Pulkki-Råback, L ...
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Cachón Alonso, L ...
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Pentti, Jaana
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visa fler...
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Nyberg, Solja T.
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Suominen, Sakari
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Vahtera, Jussi
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Lipsanen, Jari
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Batty, G. David
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Hakulinen, Chris ...
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Kivimäki, Mika
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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The Lancet Publi ...
- Av lärosätet
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Högskolan i Skövde