Sökning: WFRF:(Slager Susan L.) > (2012) > 19p13.1 is a triple...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 08948naa a2202161 4500 | |
001 | oai:DiVA.org:uu-171130 | |
003 | SwePub | |
008 | 120315s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:124381503 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1711302 URI |
024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-11-33642 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1243815032 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Stevens, Kristen N4 aut |
245 | 1 0 | a 19p13.1 is a triple negative-specific breast cancer susceptibility locus |
264 | 1 | c 2012 |
338 | a print2 rdacarrier | |
520 | a The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways. | |
700 | 1 | a Fredericksen, Zachary4 aut |
700 | 1 | a Vachon, Celine M4 aut |
700 | 1 | a Wang, Xianshu4 aut |
700 | 1 | a Margolin, Sarau Karolinska Institutet4 aut |
700 | 1 | a Lindblom, Annikau Karolinska Institutet4 aut |
700 | 1 | a Nevanlinna, Heli4 aut |
700 | 1 | a Greco, Dario4 aut |
700 | 1 | a Aittomäki, Kristiina4 aut |
700 | 1 | a Blomqvist, Carlu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)carlblom |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Vrieling, Alina4 aut |
700 | 1 | a Flesch-Janys, Dieter4 aut |
700 | 1 | a Sinn, Hans-Peter4 aut |
700 | 1 | a Wang-Gohrke, Shan4 aut |
700 | 1 | a Nickels, Stefan4 aut |
700 | 1 | a Brauch, Hiltrud4 aut |
700 | 1 | a Ko, Yon-Dschun4 aut |
700 | 1 | a Fischer, Hans-Peter4 aut |
700 | 1 | a Network, The Genica4 aut |
700 | 1 | a Schmutzler, Rita K4 aut |
700 | 1 | a Meindl, Alfons4 aut |
700 | 1 | a Bartram, Claus R4 aut |
700 | 1 | a Schott, Sarah4 aut |
700 | 1 | a Engel, Christoph4 aut |
700 | 1 | a Godwin, Andrew K4 aut |
700 | 1 | a Weaver, Joellen4 aut |
700 | 1 | a Pathak, Harsh B4 aut |
700 | 1 | a Sharma, Priyanka4 aut |
700 | 1 | a Brenner, Hermann4 aut |
700 | 1 | a Muller, Heiko4 aut |
700 | 1 | a Arndt, Volker4 aut |
700 | 1 | a Stegmaier, Christa4 aut |
700 | 1 | a Miron, Penelope4 aut |
700 | 1 | a Yannoukakos, Drakoulis4 aut |
700 | 1 | a Stavropoulou, Alexandra4 aut |
700 | 1 | a Fountzilas, George4 aut |
700 | 1 | a Gogas, Helen J4 aut |
700 | 1 | a Swann, Ruth4 aut |
700 | 1 | a Dwek, Miriam4 aut |
700 | 1 | a Perkins, Katherine Anne4 aut |
700 | 1 | a Milne, Roger L4 aut |
700 | 1 | a Benítez, Javier4 aut |
700 | 1 | a Zamora, M Pilar4 aut |
700 | 1 | a Ignacio Arias Pérez, José4 aut |
700 | 1 | a Bojesen, Stig E4 aut |
700 | 1 | a Nielsen, Sune F4 aut |
700 | 1 | a Nordestgaard, Borge G4 aut |
700 | 1 | a Flyger, Henrik4 aut |
700 | 1 | a Guénel, Pascal4 aut |
700 | 1 | a Truong, Thérèse4 aut |
700 | 1 | a Menegaux, Florence4 aut |
700 | 1 | a Cordina-Duverger, Emilie4 aut |
700 | 1 | a Burwinkel, Barbara4 aut |
700 | 1 | a Marmé, Frederick4 aut |
700 | 1 | a Schneeweiss, Andreas4 aut |
700 | 1 | a Sohn, Christof4 aut |
700 | 1 | a Sawyer, Elinor4 aut |
700 | 1 | a Tomlinson, Ian4 aut |
700 | 1 | a Kerin, Michael J4 aut |
700 | 1 | a Peto, Julian4 aut |
700 | 1 | a Johnson, Nichola4 aut |
700 | 1 | a Fletcher, Olivia4 aut |
700 | 1 | a Dos Santos Silva, Isabel4 aut |
700 | 1 | a Fasching, Peter A4 aut |
700 | 1 | a Beckmann, Matthias W4 aut |
700 | 1 | a Hartmann, Arndt4 aut |
700 | 1 | a Ekici, Arif B4 aut |
700 | 1 | a Lophatananon, Artitaya4 aut |
700 | 1 | a Muir, Kenneth4 aut |
700 | 1 | a Puttawibul, Puttisaku Karolinska Institutet4 aut |
700 | 1 | a Wiangnon, Surapon4 aut |
700 | 1 | a Schmidt, Marjanka K4 aut |
700 | 1 | a Broeks, Annegien4 aut |
700 | 1 | a Braaf, Linde M4 aut |
700 | 1 | a Rosenberg, Efraim H4 aut |
700 | 1 | a Hopper, John L4 aut |
700 | 1 | a Apicella, Carmel4 aut |
700 | 1 | a Park, Daniel J4 aut |
700 | 1 | a Southey, Melissa C4 aut |
700 | 1 | a Swerdlow, Anthony J4 aut |
700 | 1 | a Ashworth, Alan4 aut |
700 | 1 | a Orr, Nick4 aut |
700 | 1 | a Schoemaker, Minouk J4 aut |
700 | 1 | a Anton-Culver, Hoda4 aut |
700 | 1 | a Ziogas, Argyrios4 aut |
700 | 1 | a Bernstein, Leslie4 aut |
700 | 1 | a Clarke Dur, Christina4 aut |
700 | 1 | a Shen, Chen-Yang4 aut |
700 | 1 | a Yu, Jyh-Cherng4 aut |
700 | 1 | a Hsu, Huan-Ming4 aut |
700 | 1 | a Hsiung, Chia-Ni4 aut |
700 | 1 | a Hamann, Ute4 aut |
700 | 1 | a Dünnebier, Thomas4 aut |
700 | 1 | a Rüdiger, Thomas4 aut |
700 | 1 | a Ulrich Ulmer, Hans4 aut |
700 | 1 | a Pharoah, Paul D P4 aut |
700 | 1 | a Dunning, Alison M4 aut |
700 | 1 | a Humphreys, Manjeet K4 aut |
700 | 1 | a Wang, Qin4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Cross, Simon S4 aut |
700 | 1 | a Reed, Malcolm W R4 aut |
700 | 1 | a Hall, Per4 aut |
700 | 1 | a Czene, Kamilau Karolinska Institutet4 aut |
700 | 1 | a Ambrosone, Christine B4 aut |
700 | 1 | a Ademuyiwa, Foluso4 aut |
700 | 1 | a Hwang, Helena4 aut |
700 | 1 | a Eccles, Diana M4 aut |
700 | 1 | a Garcia-Closas, Montserrat4 aut |
700 | 1 | a Figueroa, Jonine D4 aut |
700 | 1 | a Sherman, Mark E4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Devilee, Peter4 aut |
700 | 1 | a Seynaeve, Caroline4 aut |
700 | 1 | a Tollenaar, R A E M4 aut |
700 | 1 | a Hooning, Maartje J4 aut |
700 | 1 | a Andrulis, Irene L4 aut |
700 | 1 | a Knight, Julia A4 aut |
700 | 1 | a Glendon, Gord4 aut |
700 | 1 | a Mulligan, Anna Marie4 aut |
700 | 1 | a Winqvist, Robert4 aut |
700 | 1 | a Pylkäs, Katri4 aut |
700 | 1 | a Jukkola-Vuorinen, Arja4 aut |
700 | 1 | a Grip, Mervi4 aut |
700 | 1 | a John, Esther M4 aut |
700 | 1 | a Miron, Alexander4 aut |
700 | 1 | a Grenaker Alnaes, Grethe4 aut |
700 | 1 | a Kristensen, Vessela4 aut |
700 | 1 | a Borresen-Dale, Anne-Lise4 aut |
700 | 1 | a Giles, Graham G4 aut |
700 | 1 | a Baglietto, Laura4 aut |
700 | 1 | a McLean, Catriona A4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Kosel, Matthew L4 aut |
700 | 1 | a Pankratz, V Shane4 aut |
700 | 1 | a Slager, Susan4 aut |
700 | 1 | a Olson, Janet E4 aut |
700 | 1 | a Radice, Paolo4 aut |
700 | 1 | a Peterlongo, Paolo4 aut |
700 | 1 | a Manoukian, Siranoush4 aut |
700 | 1 | a Barile, Monica4 aut |
700 | 1 | a Lambrechts, Diether4 aut |
700 | 1 | a Hatse, Sigrid4 aut |
700 | 1 | a Dieudonne, Anne-Sophie4 aut |
700 | 1 | a Christiaens, Marie-Rose4 aut |
700 | 1 | a Chenevix-Trench, Georgia4 aut |
700 | 1 | a Investigators, Kconfab4 aut |
700 | 1 | a Group, Aocs4 aut |
700 | 1 | a Beesley, Jonathan4 aut |
700 | 1 | a Chen, Xiaoqing4 aut |
700 | 1 | a Mannermaa, Arto4 aut |
700 | 1 | a Kosma, Veli-Matti4 aut |
700 | 1 | a Hartikainen, Jaana M4 aut |
700 | 1 | a Soini, Ylermi4 aut |
700 | 1 | a Easton, Douglas F4 aut |
700 | 1 | a Couch, Fergus J4 aut |
710 | 2 | a Karolinska Institutetb Enheten för onkologi4 org |
773 | 0 | t Cancer Researchg 72, s. 1795-q 72<1795-x 0008-5472x 1538-7445 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171130 |
856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-11-3364 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124381503 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy