WFRF:(Small Eric J)
Sökning: WFRF:(Small Eric J) > (2005-2009) > Genome-wide and fin...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05264naa a2201249 4500 | |
| 001 | oai:DiVA.org:su-33026 | |
| 003 | SwePub | |
| 008 | 091218s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-330262 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.3882 DOI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jallow, Muminatou4 aut |
| 245 | 1 0 | a Genome-wide and fine-resolution association analysis of malaria in West Africa. |
| 264 | c 2009-05-24 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2009 |
| 338 | a print2 rdacarrier | |
| 500 | a 81 författare totalt | |
| 520 | a We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 x 10(-7) to P = 4 x 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations. | |
| 700 | 1 | a Teo, Yik Ying4 aut |
| 700 | 1 | a Small, Kerrin S4 aut |
| 700 | 1 | a Rockett, Kirk A4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Clark, Taane G4 aut |
| 700 | 1 | a Kivinen, Katja4 aut |
| 700 | 1 | a Bojang, Kalifa A4 aut |
| 700 | 1 | a Conway, David J4 aut |
| 700 | 1 | a Pinder, Margaret4 aut |
| 700 | 1 | a Sirugo, Giorgio4 aut |
| 700 | 1 | a Sisay-Joof, Fatou4 aut |
| 700 | 1 | a Usen, Stanley4 aut |
| 700 | 1 | a Auburn, Sarah4 aut |
| 700 | 1 | a Bumpstead, Suzannah J4 aut |
| 700 | 1 | a Campino, Susana4 aut |
| 700 | 1 | a Coffey, Alison4 aut |
| 700 | 1 | a Dunham, Andrew4 aut |
| 700 | 1 | a Fry, Andrew E4 aut |
| 700 | 1 | a Green, Angela4 aut |
| 700 | 1 | a Gwilliam, Rhian4 aut |
| 700 | 1 | a Hunt, Sarah E4 aut |
| 700 | 1 | a Inouye, Michael4 aut |
| 700 | 1 | a Jeffreys, Anna E4 aut |
| 700 | 1 | a Mendy, Alieu4 aut |
| 700 | 1 | a Palotie, Aarno4 aut |
| 700 | 1 | a Potter, Simon4 aut |
| 700 | 1 | a Ragoussis, Jiannis4 aut |
| 700 | 1 | a Rogers, Jane4 aut |
| 700 | 1 | a Rowlands, Kate4 aut |
| 700 | 1 | a Somaskantharajah, Elilan4 aut |
| 700 | 1 | a Whittaker, Pamela4 aut |
| 700 | 1 | a Widden, Claire4 aut |
| 700 | 1 | a Donnelly, Peter4 aut |
| 700 | 1 | a Howie, Bryan4 aut |
| 700 | 1 | a Marchini, Jonathan4 aut |
| 700 | 1 | a Morris, Andrew4 aut |
| 700 | 1 | a Sanjoaquin, Miguel4 aut |
| 700 | 1 | a Achidi, Eric Akum4 aut |
| 700 | 1 | a Agbenyega, Tsiri4 aut |
| 700 | 1 | a Allen, Angela4 aut |
| 700 | 1 | a Amodu, Olukemi4 aut |
| 700 | 1 | a Corran, Patrick4 aut |
| 700 | 1 | a Djimde, Abdoulaye4 aut |
| 700 | 1 | a Dolo, Amagana4 aut |
| 700 | 1 | a Doumbo, Ogobara K4 aut |
| 700 | 1 | a Drakeley, Chris4 aut |
| 700 | 1 | a Dunstan, Sarah4 aut |
| 700 | 1 | a Evans, Jennifer4 aut |
| 700 | 1 | a Farrar, Jeremy4 aut |
| 700 | 1 | a Fernando, Deepika4 aut |
| 700 | 1 | a Hien, Tran Tinh4 aut |
| 700 | 1 | a Horstmann, Rolf D4 aut |
| 700 | 1 | a Ibrahim, Muntaser4 aut |
| 700 | 1 | a Karunaweera, Nadira4 aut |
| 700 | 1 | a Kokwaro, Gilbert4 aut |
| 700 | 1 | a Koram, Kwadwo A4 aut |
| 700 | 1 | a Lemnge, Martha4 aut |
| 700 | 1 | a Makani, Julie4 aut |
| 700 | 1 | a Marsh, Kevin4 aut |
| 700 | 1 | a Michon, Pascal4 aut |
| 700 | 1 | a Modiano, David4 aut |
| 700 | 1 | a Molyneux, Malcolm E4 aut |
| 700 | 1 | a Mueller, Ivo4 aut |
| 700 | 1 | a Parker, Michael4 aut |
| 700 | 1 | a Peshu, Norbert4 aut |
| 700 | 1 | a Plowe, Christopher V4 aut |
| 700 | 1 | a Puijalon, Odile4 aut |
| 700 | 1 | a Reeder, John4 aut |
| 700 | 1 | a Reyburn, Hugh4 aut |
| 700 | 1 | a Riley, Eleanor M4 aut |
| 700 | 1 | a Sakuntabhai, Anavaj4 aut |
| 700 | 1 | a Singhasivanon, Pratap4 aut |
| 700 | 1 | a Sirima, Sodiomon4 aut |
| 700 | 1 | a Tall, Adama4 aut |
| 700 | 1 | a Taylor, Terrie E4 aut |
| 700 | 1 | a Thera, Mahamadou4 aut |
| 700 | 1 | a Troye-Blomberg, Maritau Stockholms universitet,Avdelningen för immunologi4 aut0 (Swepub:su)marita |
| 700 | 1 | a Williams, Thomas N4 aut |
| 700 | 1 | a Wilson, Michael4 aut |
| 700 | 1 | a Kwiatkowski, Dominic P4 aut |
| 710 | 2 | a Stockholms universitetb Avdelningen för immunologi4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg , s. 657-665q <657-665x 1061-4036x 1546-1718 |
| 856 | 4 | u https://www.nature.com/articles/ng.388.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-33026 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.388 |
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- Jallow, Muminato ...
- Teo, Yik Ying
- Small, Kerrin S
- Rockett, Kirk A
- Deloukas, Panos
- Clark, Taane G
- visa fler...
- Kivinen, Katja
- Bojang, Kalifa A
- Conway, David J
- Pinder, Margaret
- Sirugo, Giorgio
- Sisay-Joof, Fato ...
- Usen, Stanley
- Auburn, Sarah
- Bumpstead, Suzan ...
- Campino, Susana
- Coffey, Alison
- Dunham, Andrew
- Fry, Andrew E
- Green, Angela
- Gwilliam, Rhian
- Hunt, Sarah E
- Inouye, Michael
- Jeffreys, Anna E
- Mendy, Alieu
- Palotie, Aarno
- Potter, Simon
- Ragoussis, Jiann ...
- Rogers, Jane
- Rowlands, Kate
- Somaskantharajah ...
- Whittaker, Pamel ...
- Widden, Claire
- Donnelly, Peter
- Howie, Bryan
- Marchini, Jonath ...
- Morris, Andrew
- Sanjoaquin, Migu ...
- Achidi, Eric Aku ...
- Agbenyega, Tsiri
- Allen, Angela
- Amodu, Olukemi
- Corran, Patrick
- Djimde, Abdoulay ...
- Dolo, Amagana
- Doumbo, Ogobara ...
- Drakeley, Chris
- Dunstan, Sarah
- Evans, Jennifer
- Farrar, Jeremy
- Fernando, Deepik ...
- Hien, Tran Tinh
- Horstmann, Rolf ...
- Ibrahim, Muntase ...
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- Kokwaro, Gilbert
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- Riley, Eleanor M
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- Sirima, Sodiomon
- Tall, Adama
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