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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05096naa a2200781 4500 | |
| 001 | oai:lup.lub.lu.se:368be195-5924-4481-b0c3-d01904609fea | |
| 003 | SwePub | |
| 008 | 160401s2003 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1937359 | |
| 009 | oai:DiVA.org:uu-65561 | |
| 024 | 7 | a https://lup.lub.lu.se/record/3093122 URI |
| 024 | 7 | a https://doi.org/10.1002/ddr.101702 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19373592 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-655612 URI |
| 040 | a (SwePub)lud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a kon2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Fredholm, BBu Karolinska Institutet4 aut |
| 245 | 1 0 | a Consequences of eliminating adenosine A(1) receptors in mice |
| 264 | c 2003-05-22 | |
| 264 | 1 | b Wiley,c 2003 |
| 520 | a The second coding exon of the adenosine A, receptor gene was eliminated by homologous recombination. The phenotype of mice (mixed C57B6/129OlaHsd background) was studied, using siblings from matings of heterozygous mice. Among the offspring the ratio between+/+, +/-and -/-animals was 1:2:1. Over the first half-year-at least-growth and viability were the same in all genotypes. Binding of A(1) ligands was eliminated in-/-mice and halved in+/-mice. Blood pressure was increased in-/-mice and this was paralleled by an increase in plasma renin. Heart rate was unaffected, as was contractility. Furthermore, the response of the perfused heart to ischemia was similar in+/+and -/-hearts. However, remote preconditioning was eliminated in-/-mouse hearts. Tubuloglomerular feedback in the kidney was also lost in-/-mice. The analgesic response to a non-selective adenosing receptor agonist was lost in-/-mice, which also showed hyperalgesia in the tail-flick test. There was a slight hypoactivity in-/-mice, but responses to caffeine were essentially normal. The inhibition of excitatory neurotransmission in hippocampus by adenosine was lost in-/-mice and reduced in+/-mice. Responses to ATP were affected similarly. Hypoxic depression of synaptic transmission was essentially eliminated in hippocampus and hypoxic decrease in spinal respiratory neuron firing was markedly reduced. These results show that adenosine A, receptors play a physiologically important role in the kidney, spinal cord, and hippocampus and that they are critically important in the adaptive responses to hypoxia. (C) 2003 Wiley-Liss, Inc. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a pain | |
| 653 | a mice | |
| 653 | a anxiety | |
| 653 | a hypoxia | |
| 653 | a adenosine A(1) receptor gene | |
| 700 | 1 | a Halldner, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Johansson, C4 aut |
| 700 | 1 | a Schulte, Gu Karolinska Institutet4 aut |
| 700 | 1 | a Lovdahl, Cu Karolinska Institutet4 aut |
| 700 | 1 | a Thoren, P4 aut |
| 700 | 1 | a Dunwiddie, TV4 aut |
| 700 | 1 | a Masino, SA4 aut |
| 700 | 1 | a Poelchen, W4 aut |
| 700 | 1 | a Diao, LH4 aut |
| 700 | 1 | a Illes, P4 aut |
| 700 | 1 | a Zahniser, NR4 aut |
| 700 | 1 | a Valen, G4 aut |
| 700 | 1 | a Tokuno, S4 aut |
| 700 | 1 | a Sommerschild, H4 aut |
| 700 | 1 | a Gimenez-Llort, L4 aut |
| 700 | 1 | a Fernandez-Teruel, A4 aut |
| 700 | 1 | a Escorihuela, RM4 aut |
| 700 | 1 | a Wiesenfeld-Hallin, Zu Karolinska Institutet4 aut |
| 700 | 1 | a Xu, XJu Karolinska Institutet4 aut |
| 700 | 1 | a Hardemark, A4 aut |
| 700 | 1 | a Herlenius, Eu Karolinska Institutet4 aut |
| 700 | 1 | a Pekny, S4 aut |
| 700 | 1 | a Gebre-Medhin, Samuelu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mphy-sgm |
| 700 | 1 | a Brown, Ru Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
| 700 | 1 | a Ollerstam, Au Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
| 700 | 1 | a Persson, AEGu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
| 700 | 1 | a Skott, O4 aut |
| 700 | 1 | a Johansson, Bu Karolinska Institutet4 aut |
| 700 | 1 | a Pekny, M4 aut |
| 710 | 2 | a Karolinska Institutetb Avdelningen för klinisk genetik4 org |
| 773 | 0 | t Drug Development Research (Proceedings of the Seventh International Symposium on Adenosine and Adenine Nucleotides - Part 1)d : Wileyg 58, s. 350-q 58:4<350-353x 1098-2299x 0272-4391 |
| 773 | 0 | t Drug Dev Resd : Wileyg 58, s. 350-q 58<350- |
| 856 | 4 | u http://dx.doi.org/10.1002/ddr.10170y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/309312 |
| 856 | 4 8 | u https://doi.org/10.1002/ddr.10170 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1937359 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-65561 |
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