Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways.

Delaney, Joseph R (author)

Stöven, Svenja (author): Umeå universitet,Institutionen för klinisk mikrobiologi,Klinisk bakteriologi

Uvell, Hanna (author)

Anderson, Kathryn V (author)

Engström, Y (author): Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik

Mlodzik, Marek (author)

(creator_code:org_t)

2006-06-08
2006
English.
In: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 25:13, s. 3068-77

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Abstract Subject headings

Jun N-terminal kinase (JNK) signaling is a highly conserved pathway that controls both cytoskeletal remodeling and transcriptional regulation in response to a wide variety of signals. Despite the importance of JNK in the mammalian immune response, and various suggestions of its importance in Drosophila immunity, the actual contribution of JNK signaling in the Drosophila immune response has been unclear. Drosophila TAK1 has been implicated in the NF-kappaB/Relish-mediated activation of antimicrobial peptide genes. However, we demonstrate that Relish activation is intact in dTAK1 mutant animals, and that the immune response in these mutant animals was rescued by overexpression of a downstream JNKK. The expression of a JNK inhibitor and induction of JNK loss-of-function clones in immune responsive tissue revealed a general requirement for JNK signaling in the expression of antimicrobial peptides. Our data indicate that dTAK1 is not required for Relish activation, but instead is required in JNK signaling for antimicrobial peptide gene expression.

By the author/editor: Delaney, Joseph ...; Stöven, Svenja; Uvell, Hanna; Anderson, Kathry ...; Engström, Y; Mlodzik, Marek

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