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Sökning: WFRF:(Stohr W.) > Neonatal invasive c...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04203naa a2200805 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:152940344 | |
| 003 | SwePub | |
| 008 | 240701s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1529403442 URI |
| 024 | 7 | a https://doi.org/10.1093/mmy/myad0102 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cook, A4 aut |
| 245 | 1 0 | a Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study |
| 264 | c 2023-03-06 | |
| 264 | 1 | b Oxford University Press (OUP),c 2023 |
| 520 | a Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those neonates affected with NIC and of fluconazole-resistant Candida spp. isolates in low- and middle-income countries (LMICs) compared to high-income countries (HICs). We describe the epidemiology, Candida spp. distribution, treatment, and outcomes of neonates with NIC from LMICs enrolled in a global, prospective, longitudinal, observational cohort study (NeoOBS) of hospitalized infants <60 days postnatal age with sepsis (August 2018–February 2021). A total of 127 neonates from 14 hospitals in 8 countries with Candida spp. isolated from blood culture were included. Median gestational age of affected neonates was 30 weeks (IQR: 28–34), and median birth weight was 1270 gr (interquartile range [IQR]: 990–1692). Only a minority had high-risk criteria, such as being born <28 weeks, 19% (24/127), or birth weight <1000 gr, 27% (34/127). The most common Candida species were C. albicans (n = 45, 35%), C. parapsilosis (n = 38, 30%), and Candida auris (n = 18, 14%). The majority of C. albicans isolates were fluconazole susceptible, whereas 59% of C. parapsilosis isolates were fluconazole-resistant. Amphotericin B was the most common antifungal used [74% (78/105)], followed by fluconazole [22% (23/105)]. Death by day 28 post-enrollment was 22% (28/127). To our knowledge, this is the largest multi-country cohort of NIC in LMICs. Most of the neonates would not have been considered at high risk for NIC in HICs. A substantial proportion of isolates was resistant to first choice fluconazole. Understanding the burden of NIC in LMIC is essential to guide future research and treatment guidelines. | |
| 700 | 1 | a Ferreras-Antolin, L4 aut |
| 700 | 1 | a Adhisivam, B4 aut |
| 700 | 1 | a Ballot, D4 aut |
| 700 | 1 | a Berkley, JA4 aut |
| 700 | 1 | a Bernaschi, P4 aut |
| 700 | 1 | a Carvalheiro, CG4 aut |
| 700 | 1 | a Chaikittisuk, N4 aut |
| 700 | 1 | a Chen, YS4 aut |
| 700 | 1 | a Chibabhai, V4 aut |
| 700 | 1 | a Chitkara, S4 aut |
| 700 | 1 | a Chiurchiu, S4 aut |
| 700 | 1 | a Chorafa, E4 aut |
| 700 | 1 | a Dien, TM4 aut |
| 700 | 1 | a Dramowski, A4 aut |
| 700 | 1 | a de Matos, SF4 aut |
| 700 | 1 | a Feng, JX4 aut |
| 700 | 1 | a Jarovsky, D4 aut |
| 700 | 1 | a Kaur, R4 aut |
| 700 | 1 | a Khamjakkaew, W4 aut |
| 700 | 1 | a Laoyookhong, P4 aut |
| 700 | 1 | a Machanja, E4 aut |
| 700 | 1 | a Mussi-Pinhata, MM4 aut |
| 700 | 1 | a Namiiro, F4 aut |
| 700 | 1 | a Natraj, G4 aut |
| 700 | 1 | a Naziat, H4 aut |
| 700 | 1 | a Ngoc, HTB4 aut |
| 700 | 1 | a Ondongo-Ezhet, C4 aut |
| 700 | 1 | a Preedisripipat, K4 aut |
| 700 | 1 | a Rahman, H4 aut |
| 700 | 1 | a Riddell, A4 aut |
| 700 | 1 | a Roilides, E4 aut |
| 700 | 1 | a Russell, N4 aut |
| 700 | 1 | a Sastry, AS4 aut |
| 700 | 1 | a Tasimwa, HB4 aut |
| 700 | 1 | a Ji, TZ4 aut |
| 700 | 1 | a Wadula, J4 aut |
| 700 | 1 | a Wang, YJ4 aut |
| 700 | 1 | a Whitelaw, A4 aut |
| 700 | 1 | a Wu, D4 aut |
| 700 | 1 | a Yadav, V4 aut |
| 700 | 1 | a Yang, G4 aut |
| 700 | 1 | a Stohr, W4 aut |
| 700 | 1 | a Bielicki, JA4 aut |
| 700 | 1 | a Ellis, S4 aut |
| 700 | 1 | a Warris, A4 aut |
| 700 | 1 | a Heath, PT4 aut |
| 700 | 1 | a Sharland, M4 aut |
| 773 | 0 | t Medical mycologyd : Oxford University Press (OUP)g 61:3q 61:3x 1460-2709x 1369-3786 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152940344 |
| 856 | 4 8 | u https://doi.org/10.1093/mmy/myad010 |
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- Cook, A
- Ferreras-Antolin ...
- Adhisivam, B
- Ballot, D
- Berkley, JA
- Bernaschi, P
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- Carvalheiro, CG
- Chaikittisuk, N
- Chen, YS
- Chibabhai, V
- Chitkara, S
- Chiurchiu, S
- Chorafa, E
- Dien, TM
- Dramowski, A
- de Matos, SF
- Feng, JX
- Jarovsky, D
- Kaur, R
- Khamjakkaew, W
- Laoyookhong, P
- Machanja, E
- Mussi-Pinhata, M ...
- Namiiro, F
- Natraj, G
- Naziat, H
- Ngoc, HTB
- Ondongo-Ezhet, C
- Preedisripipat, ...
- Rahman, H
- Riddell, A
- Roilides, E
- Russell, N
- Sastry, AS
- Tasimwa, HB
- Ji, TZ
- Wadula, J
- Wang, YJ
- Whitelaw, A
- Wu, D
- Yadav, V
- Yang, G
- Stohr, W
- Bielicki, JA
- Ellis, S
- Warris, A
- Heath, PT
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