Sökning: WFRF:(Stram Daniel) > (2005-2009) > Quantitative trait ...
Fältnamn | Indikatorer | Metadata |
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000 | 03718naa a2200709 4500 | |
001 | oai:DiVA.org:umu-26425 | |
003 | SwePub | |
008 | 091009s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-264252 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddp3022 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ahn, Jiyoung4 aut |
245 | 1 0 | a Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). |
264 | c 2009-07-02 | |
264 | 1 | b Oxford University Press (OUP),c 2009 |
338 | a print2 rdacarrier | |
520 | a Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones. | |
700 | 1 | a Schumacher, Fredrick R4 aut |
700 | 1 | a Berndt, Sonja I4 aut |
700 | 1 | a Pfeiffer, Ruth4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Andriole, Gerald L4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Bueno-de-Mesquita, Bas4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Diver, W Ryan4 aut |
700 | 1 | a Feigelson, Heather Spencer4 aut |
700 | 1 | a Gaziano, J Michael4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Haiman, Christopher A4 aut |
700 | 1 | a Henderson, Brian E4 aut |
700 | 1 | a Hoover, Robert N4 aut |
700 | 1 | a Kolonel, Laurence N4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Ma, Jing4 aut |
700 | 1 | a Le Marchand, Loïc4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003 |
700 | 1 | a Stampfer, Meir4 aut |
700 | 1 | a Stram, Daniel O4 aut |
700 | 1 | a Thomas, Gilles4 aut |
700 | 1 | a Thun, Michael J4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Weinstein, Stephanie J4 aut |
700 | 1 | a Yeager, Meredith4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Hunter, David J4 aut |
700 | 1 | a Hayes, Richard B4 aut |
710 | 2 | a Umeå universitetb Urologi och andrologi4 org |
773 | 0 | t Human molecular geneticsd : Oxford University Press (OUP)g 18:19, s. 3749-57q 18:19<3749-57x 1460-2083x 0964-6906 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/18/19/3749/17247275/ddp302.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26425 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddp302 |
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