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Sökning: WFRF:(Stram Daniel) > (2005-2009) > Quantitative trait ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003718naa a2200709 4500
001oai:DiVA.org:umu-26425
003SwePub
008091009s2009 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-264252 URI
024a https://doi.org/10.1093/hmg/ddp3022 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Ahn, Jiyoung4 aut
2451 0a Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
264 c 2009-07-02
264 1b Oxford University Press (OUP),c 2009
338 a print2 rdacarrier
520 a Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.
700a Schumacher, Fredrick R4 aut
700a Berndt, Sonja I4 aut
700a Pfeiffer, Ruth4 aut
700a Albanes, Demetrius4 aut
700a Andriole, Gerald L4 aut
700a Ardanaz, Eva4 aut
700a Boeing, Heiner4 aut
700a Bueno-de-Mesquita, Bas4 aut
700a Chanock, Stephen J4 aut
700a Clavel-Chapelon, Françoise4 aut
700a Diver, W Ryan4 aut
700a Feigelson, Heather Spencer4 aut
700a Gaziano, J Michael4 aut
700a Giovannucci, Edward4 aut
700a Haiman, Christopher A4 aut
700a Henderson, Brian E4 aut
700a Hoover, Robert N4 aut
700a Kolonel, Laurence N4 aut
700a Kraft, Peter4 aut
700a Ma, Jing4 aut
700a Le Marchand, Loïc4 aut
700a Overvad, Kim4 aut
700a Palli, Domenico4 aut
700a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003
700a Stampfer, Meir4 aut
700a Stram, Daniel O4 aut
700a Thomas, Gilles4 aut
700a Thun, Michael J4 aut
700a Travis, Ruth C4 aut
700a Trichopoulos, Dimitrios4 aut
700a Virtamo, Jarmo4 aut
700a Weinstein, Stephanie J4 aut
700a Yeager, Meredith4 aut
700a Kaaks, Rudolf4 aut
700a Hunter, David J4 aut
700a Hayes, Richard B4 aut
710a Umeå universitetb Urologi och andrologi4 org
773t Human molecular geneticsd : Oxford University Press (OUP)g 18:19, s. 3749-57q 18:19<3749-57x 1460-2083x 0964-6906
856u https://academic.oup.com/hmg/article-pdf/18/19/3749/17247275/ddp302.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26425
8564 8u https://doi.org/10.1093/hmg/ddp302

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