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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005110naa a2200565 4500
001oai:DiVA.org:uu-421678
003SwePub
008201012s2013 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:b2a19bad-66c8-4b5d-ba9d-0282d5a4eab5
009oai:prod.swepub.kib.ki.se:126570458
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4216782 URI
0247 a https://doi.org/10.4049/jimmunol.12007282 DOI
0247 a https://lup.lub.lu.se/record/37390872 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1265704582 URI
040 a (SwePub)uud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bergman, Petra4 aut
2451 0a Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats.
264 c 2013-04-15
264 1b The American Association of Immunologists,c 2013
338 a print2 rdacarrier
520 a MicroRNAs (miRNAs) are known to regulate most biological processes and have been found dysregulated in a variety of diseases, including multiple sclerosis (MS). In this study, we characterized miRNAs that associate with susceptibility to develop experimental autoimmune encephalomyelitis (EAE) in rats, a well-established animal model of MS. Using Illumina next-generation sequencing, we detected 544 miRNAs in the lymph nodes of EAE-susceptible Dark Agouti and EAE-resistant Piebald Virol Glaxo rats during immune activation. Forty-three miRNAs were found differentially expressed between the two strains, with 81% (35 out of 43) showing higher expression in the susceptible strain. Only 33% of tested miRNAs displayed differential expression in naive lymph nodes, suggesting that a majority of regulated miRNAs are EAE dependent. Further investigation of a selected six miRNAs indicates differences in cellular source and kinetics of expression. Several of the miRNAs, including miR-146a, miR-21, miR-181a, miR-223, and let-7, have previously been implicated in immune system regulation. Moreover, 77% (33 out of 43) of the miRNAs were associated with MS and other autoimmune diseases. Target genes likely regulated by the miRNAs were identified using computational predictions combined with whole-genome expression data. Differentially expressed miRNAs and their targets involve functions important for MS and EAE, such as immune cell migration through targeting genes like Cxcr3 and cellular maintenance and signaling by regulation of Prkcd and Stat1. In addition, we demonstrated that these three genes are direct targets of miR-181a. Our study highlights the impact of multiple miRNAs, displaying diverse kinetics and cellular sources, on development of pathogenic autoimmune inflammation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a James, Tojou Karolinska Institutet4 aut
7001 a Kular, Larau Karolinska Institutet4 aut
7001 a Ruhrmann, Sabrinau Karolinska Institutet4 aut
7001 a Kramarova, Tatiana4 aut
7001 a Kvist, Andersu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ekol-akv
7001 a Supic, Gordana4 aut
7001 a Gillett, Alan4 aut
7001 a Pivarcsi, Andoru Karolinska Institutet4 aut0 (Swepub:uu)andpi932
7001 a Jagodic, Majau Karolinska Institutet4 aut
7102 a Karolinska Institutetb Bröstcancer-genetik4 org
7730 t Journal of Immunologyd : The American Association of Immunologistsg 190:8, s. 4066-75q 190:8<4066-75x 0022-1767x 1550-6606
8564 u https://www.jimmunol.org/content/jimmunol/190/8/4066.full.pdf
8564 u http://dx.doi.org/10.4049/jimmunol.1200728x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421678
8564 8u https://doi.org/10.4049/jimmunol.1200728
8564 8u https://lup.lub.lu.se/record/3739087
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126570458

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