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Loss of a close fam...
Loss of a close family member the year before or during pregnancy and the risk of placental abruption : a cohort study from Denmark and Sweden
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- Laszlo, K. D. (författare)
- Karolinska Institutet
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Ananth, C. V. (författare)
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- Wikström, Anna-Karin (författare)
- Karolinska Institutet,Uppsala universitet,Obstetrik & gynekologi
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- Svensson, T. (författare)
- Karolinska Institutet
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Li, J. (författare)
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Olsen, J. (författare)
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Vestergaard, M. (författare)
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Obel, C. (författare)
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- Cnattingius, S. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2014
- 2014
- Engelska.
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Ingår i: Psychological Medicine. - 0033-2917 .- 1469-8978. ; 44:9, s. 1855-1866
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Maternal stress during pregnancy is associated with a modestly increased risk of fetal growth restriction and pre-eclampsia. Since placental abruption shares similar pathophysiological mechanisms and risk factors with fetal growth restriction and pre-eclampsia, we hypothesized that maternal stress may be implicated in abruption risk. We investigated the association between maternal bereavement during pregnancy and placental abruption. Method We studied singleton births in Denmark (1978-2008) and Sweden (1973-2006) (n=5103272). In nationwide registries, we obtained data on death of women's close family members (older children, siblings, parents, and partners), abruption and potential confounders. Results A total of 30312 (6/1000) pregnancies in the cohort were diagnosed with placental abruption. Among normotensive women, death of a child the year before or during pregnancy was associated with a 54% increased odds of abruption [95% confidence interval (CI) 1.30-1.82]; the increased odds were restricted to women who lost a child the year before or during the first trimester in pregnancy. In the group with chronic hypertension, death of a child the year before or in the first trimester of pregnancy was associated with eight-fold increased odds of abruption (odds ratio 8.17, 95% CI 3.17-21.10). Death of other relatives was not associated with abruption risk. Conclusions Loss of a child the year before or in the first trimester of pregnancy was associated with an increased risk of abruption, especially among women with chronic hypertension. Studies are needed to investigate the effect of less severe, but more frequent, sources of stress on placental abruption risk.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Bereavement
- cohort study
- placental abruption
- stress
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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