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Sökning: WFRF:(Takayama J.) > (2000-2004) > The predictive valu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003442naa a2200385 4500
001oai:lup.lub.lu.se:eb168e96-dbf9-4da4-90a9-a65fd71ffd6e
003SwePub
008160401s2002 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/3420852 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Sjostrom, J4 aut
2451 0a The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer
264 1c 2002
520 a Purpose: The purpose was to evaluate the utility of some bcl-2 family proteins fas and fasL as predictive indicators for chemotherapy response in advanced breast cancer. Experimental Design: Between October 1994 and October 1997, 283 patients with advanced breast cancer were included in a multicenter randomized study comparing docetaxel (D) to sequential methotrexate and 5-fluorouracil (MF) after anthracycline failure. The response rates (complete response + partial response) were 42 and 21% in the D and MF arms, respectively (P < 0.001). In 126 patients, histological blocks of primary tumors were available for inummohistochemical analysis of bax, bcl-2, bcl-xL, bag-1, fas and fasL. Results: Of the investigated factors, bag-1 correlated positively with bax, bcl-2, and fasL, and fasL correlated positively with fas and bax. None of these apoptosis-related factors was associated with a response to chemotherapy either in the whole patient population or in the D or MF arms. Interestingly, low bcl-2 expression was associated with shorter time to progression (P = 0.02) and shorter overall survival (OS; P = 0.001). High fasL expression showed a trend toward shorter OS. In multivariate backwards stepwise Cox analysis, in which histological grade and estrogen receptor status (ER) were also included, bcl-2 (P = 0.01) and fasL (P = 0.005) remained highly significantly associated with OS, whereas histological grade and ER lost their significance. Conclusions: None of the investigated apoptosis-related factors of primary tumor could predict the later response to either D or MF treatment. However, fasL and bcl-2 were strong prognostic factors. Patients who had tumors with high fasL and low bcl-2 expression had the shortest OS.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Blomqvist, C4 aut
7001 a von Boguslawski, K4 aut
7001 a Bengtsson, NO4 aut
7001 a Mjaaland, I4 aut
7001 a Malmström, Peru Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-pma
7001 a Ostenstadt, B4 aut
7001 a Wist, E4 aut
7001 a Valvere, V4 aut
7001 a Takayama, S4 aut
7001 a Reed, JC4 aut
7001 a Saksela, E4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t Clinical Cancer Researchg 8:3, s. 811-816q 8:3<811-816x 1078-0432
8564 u http://clincancerres.aacrjournals.org/cgi/content/abstract/8/3/811x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/342085

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