Sökning: WFRF:(Tan Shouyong)
> (2019) >
Quinoline Derivativ...
Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
-
- Makafe, Gaelle G. (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Hussain, Muzammal (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Chinese Acad Sci, Guangdong Prov Key Lab Biocomp, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Surineni, Goverdhan (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
visa fler...
-
- Tan, Yaoju (författare)
- Guangzhou Chest Hosp, Dept Clin Lab, State Key Lab Resp Dis, 62 Hengzhigang Rd, Guangzhou 510095, Guangdong, Peoples R China.
-
- Wong, Nai-Kei (författare)
- Southern Univ Sci & Technol, Hosp 2, Shenzhen Peoples Hosp 3, Key Discipline Infect Dis, 29 Bulan Rd, Shenzhen 518112, Peoples R China.
-
- Julius, Mugweru (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Embu, Dept Biol Sci, Embu 660100, Kenya.
-
- Liu, Lanying (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Gift, Chiwala (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Jiang, Huofeng (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Sci & Technol China, Sch Life Sci, 96 Jinzhai Rd, Hefei 230027, Anhui, Peoples R China.
-
- Tang, Yunxiang (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Anhui Univ, Inst Phys Sci & Informat Technol, 111 Jiulong Rd, Hefei 230009, Anhui, Peoples R China.
-
- Liu, Jianxiong (författare)
- Guangzhou Chest Hosp, Dept Clin Lab, State Key Lab Resp Dis, 62 Hengzhigang Rd, Guangzhou 510095, Guangdong, Peoples R China.
-
- Tan, Shouyong (författare)
- Guangzhou Chest Hosp, Dept Clin Lab, State Key Lab Resp Dis, 62 Hengzhigang Rd, Guangzhou 510095, Guangdong, Peoples R China.
-
- Yu, Zhijun (författare)
- Chinese Acad Sci, Guangdong Prov Key Lab Biocomp, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Liu, Zhiyong (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.
-
- Lu, Zhili (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.
-
- Fang, Cuiting (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Zhou, Yang, 1986- (författare)
- KTH,Teoretisk kemi och biologi
-
- Zhang, Jiancun (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Chinese Acad Sci, Guangdong Prov Key Lab Biocomp, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Zhu, Qiang (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Liu, Jinsong (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Chinese Acad Sci, Guangdong Prov Key Lab Biocomp, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
- Zhang, Tianyu (författare)
- Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China.
-
visa färre...
-
Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China;Guangzhou Regenerat Med & Hlth Guangdong Lab GRM, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China. Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Chinese Acad Sci, Guangdong Prov Key Lab Biocomp, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Ave,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.;Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China. (creator_code:org_t)
- CELL PRESS, 2019
- 2019
- Engelska.
-
Ingår i: Cell Chemical Biology. - : CELL PRESS. - 2451-9456 .- 2451-9448. ; 26:8, s. 1187-
- Relaterad länk:
-
http://www.cell.com/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- There is a great need for identification and development of new anti-tuberculosis drugs with novel targets. Recent drug-discovery efforts typically focus on identifying inhibitors but not activators that perturb metabolic enzymes' functions as a means to kill Mycobacterium tuberculosis (Mtb). Here, we describe a class of quinoline compounds, Z0933/Z0930, which kill Mtb by acting as activators of glutamate kinase (GK), a previously untargeted enzyme catalyzing the first step of proline biosynthesis. We further show that Z0933/Z0930 augment proline production and induce Mtb killing via proline-derived redox imbalance and production of reactive oxygen species. This work highlights the effectiveness of gain-of-function probes against Mtb and provides a framework for the discovery of next-generation allosteric activators of GK.
Ämnesord
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Makafe, Gaelle G ...
-
Hussain, Muzamma ...
-
Surineni, Goverd ...
-
Tan, Yaoju
-
Wong, Nai-Kei
-
Julius, Mugweru
-
visa fler...
-
Liu, Lanying
-
Gift, Chiwala
-
Jiang, Huofeng
-
Tang, Yunxiang
-
Liu, Jianxiong
-
Tan, Shouyong
-
Yu, Zhijun
-
Liu, Zhiyong
-
Lu, Zhili
-
Fang, Cuiting
-
Zhou, Yang, 1986 ...
-
Zhang, Jiancun
-
Zhu, Qiang
-
Liu, Jinsong
-
Zhang, Tianyu
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Kemi
-
och Teoretisk kemi
- Artiklar i publikationen
-
Cell Chemical Bi ...
- Av lärosätet
-
Kungliga Tekniska Högskolan