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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14179naa a2203637 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141158520 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:62df79a8-ffb3-4fc5-8c2e-ef4cf0b28694 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1411585202 URI |
| 024 | 7 | a https://doi.org/10.1136/annrheumdis-2018-2148162 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/62df79a8-ffb3-4fc5-8c2e-ef4cf0b286942 URI |
| 040 | a (SwePub)kid (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Elhai, Mu Paris Descartes University,Carol Davila University of Medicine and Pharmacy4 aut |
| 245 | 1 0 | a Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study |
| 264 | c 2019-04-09 | |
| 264 | 1 | b BMJ,c 2019 |
| 520 | a To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 653 | a lung fibrosis | |
| 653 | a rituximab | |
| 653 | a skin fibrosis | |
| 653 | a systemic sclerosis | |
| 700 | 1 | a Boubaya, Mu University of Paris VIII4 aut |
| 700 | 1 | a Distler, Ou University Hospital of Zurich4 aut |
| 700 | 1 | a Smith, Vu Ghent University Hospital4 aut |
| 700 | 1 | a Matucci-Cerinic, Mu University of Florence4 aut |
| 700 | 1 | a Sancho, JJu Hospital Universitario Doctor Peset4 aut |
| 700 | 1 | a Truchetet, MEu Centre Hospitalier Universitaire de Bordeaux4 aut |
| 700 | 1 | a Braun-Moscovici, Yu Technion - Israel Institute of Technology4 aut |
| 700 | 1 | a Iannone, Fu University of Bari Aldo Moro4 aut |
| 700 | 1 | a Novikov, PIu I.M. Sechenov First Moscow State Medical University4 aut |
| 700 | 1 | a Lescoat, Au Rennes University Hospital4 aut |
| 700 | 1 | a Siegert, Eu Charité - University Medicine Berlin4 aut |
| 700 | 1 | a Castellvi, Iu Hospital de Sant Pau4 aut |
| 700 | 1 | a Airo, Pu Spedali Civili Di Brescia4 aut |
| 700 | 1 | a Vettori, Su Second University of Napels4 aut |
| 700 | 1 | a Langhe, Eu Catholic University of Leuven4 aut |
| 700 | 1 | a Hachulla, Eu Lille University Hospital4 aut |
| 700 | 1 | a Erler, Au Medizinsche Klinik und Poliklinik I, Dresden4 aut |
| 700 | 1 | a Ananieva, Lu V.A. Nasonova Research Institute of Rheumatology4 aut |
| 700 | 1 | a Krusche, Mu Asklepios Klinik Altona4 aut |
| 700 | 1 | a Lopez-Longo, FJu Hospital Universitario Quirón4 aut |
| 700 | 1 | a Distler, JHWu Friedrich-Alexander University Erlangen-Nürnberg4 aut |
| 700 | 1 | a Hunzelmann, Nu University of Cologne4 aut |
| 700 | 1 | a Hoffmann-Vold, AMu Norwegian Radium Hospital4 aut |
| 700 | 1 | a Riccieri, Vu Sapienza University of Rome4 aut |
| 700 | 1 | a Hsu, VMu Rutgers University: The State University of New Jersey4 aut |
| 700 | 1 | a Pozzi, MRu San Gerardo Hospital4 aut |
| 700 | 1 | a Ancuta, Cu Clinical Hospital Dr. Ion Cantacuzino4 aut |
| 700 | 1 | a Rosato, Eu Sapienza University of Rome4 aut |
| 700 | 1 | a Mihai, C4 aut |
| 700 | 1 | a Kuwana, Mu Nippon Medical School4 aut |
| 700 | 1 | a Saketkoo, LAu Tulane University4 aut |
| 700 | 1 | a Chizzolini, Cu Geneva University Hospital4 aut |
| 700 | 1 | a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups4 aut0 (Swepub:lu)reum-rhe |
| 700 | 1 | a Ullman, Su Copenhagen University Hospital4 aut |
| 700 | 1 | a Yavuz, Su Marmara University4 aut |
| 700 | 1 | a Rednic, Su University of Medicine and Pharmacy, Cluj-Napoca4 aut |
| 700 | 1 | a Caimmi, Cu University of Verona4 aut |
| 700 | 1 | a Bloch-Queyrat, C4 aut |
| 700 | 1 | a Allanore, Yu Paris Descartes University4 aut |
| 700 | 1 | a Guiducci, S4 aut |
| 700 | 1 | a Walker, UA4 aut |
| 700 | 1 | a Kyburz, D4 aut |
| 700 | 1 | a Lapadula, G4 aut |
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| 700 | 1 | a Bielecka, OK4 aut |
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| 700 | 1 | a Vlachoyiannopoulos, PG4 aut |
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| 700 | 1 | a Carreira, PE4 aut |
| 700 | 1 | a Novak, S4 aut |
| 700 | 1 | a Czirjak, L4 aut |
| 700 | 1 | a Varju, C4 aut |
| 700 | 1 | a Kucharz, EJu Karolinska Institutet4 aut |
| 700 | 1 | a Kotulska, A4 aut |
| 700 | 1 | a Kopec-Medrek, M4 aut |
| 700 | 1 | a Widuchowska, M4 aut |
| 700 | 1 | a Cozzi, F4 aut |
| 700 | 1 | a Rozman, B4 aut |
| 700 | 1 | a Mallia, C4 aut |
| 700 | 1 | a Coleiro, B4 aut |
| 700 | 1 | a Gabrielli, A4 aut |
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| 700 | 1 | a Dhamadi, R4 aut |
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| 700 | 1 | a Mauriziano, O4 aut |
| 700 | 1 | a Caramaschi, P4 aut |
| 700 | 1 | a Morovic-Vergles, J4 aut |
| 700 | 1 | a Black, C4 aut |
| 700 | 1 | a Denton, C4 aut |
| 700 | 1 | a Damjanov, N4 aut |
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| 700 | 1 | a Herrick, A4 aut |
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| 700 | 1 | a Mendoza, AZ4 aut |
| 700 | 1 | a de la Puente, C4 aut |
| 700 | 1 | a Giraldo, WAS4 aut |
| 700 | 1 | a Midtvedt, O4 aut |
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| 700 | 1 | a Soare, A4 aut |
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| 700 | 1 | a Milicescu, M4 aut |
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| 700 | 1 | a Eyerich, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Hein, R4 aut |
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| 700 | 1 | a Mohamed, WAAA4 aut |
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| 700 | 1 | a Tanaseanu, CM4 aut |
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| 700 | 1 | a Boulman, N4 aut |
| 700 | 1 | a Rimar, D4 aut |
| 700 | 1 | a Couto, M4 aut |
| 700 | 1 | a Kahl, S4 aut |
| 700 | 1 | a Chen, F4 aut |
| 700 | 1 | a McCloskey, D4 aut |
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| 700 | 1 | a Mukhin, NA4 aut |
| 700 | 1 | a Moiseev, S4 aut |
| 710 | 2 | a Paris Descartes Universityb Carol Davila University of Medicine and Pharmacy4 org |
| 773 | 0 | t Annals of the rheumatic diseasesd : BMJg 78:7, s. 979-987q 78:7<979-987x 1468-2060x 0003-4967 |
| 856 | 4 | u http://dx.doi.org/10.1136/annrheumdis-2018-214816y FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141158520 |
| 856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2018-214816 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/62df79a8-ffb3-4fc5-8c2e-ef4cf0b28694 |
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