Sökning: WFRF:(Tapia I) > (2020-2024) > Recurrent horizonta...
Fältnamn | Indikatorer | Metadata |
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000 | 05760naa a2201477 4500 | |
001 | oai:gup.ub.gu.se/294859 | |
003 | SwePub | |
008 | 240910s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2948592 URI |
024 | 7 | a https://doi.org/10.1038/s41467-020-16765-w2 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Strakova, A.4 aut |
245 | 1 0 | a Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
264 | c 2020-06-16 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
520 | a Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a phylogenetic analysis | |
653 | a genome | |
653 | a transcription | |
653 | a sequence | |
653 | a dog | |
653 | a variants | |
653 | a dynamics | |
653 | a health | |
653 | a cell | |
653 | a tool | |
653 | a Science & Technology - Other Topics | |
700 | 1 | a Nicholls, Thomas J.u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut |
700 | 1 | a Baez-Ortega, A.4 aut |
700 | 1 | a Ni Leathlobhair, M.4 aut |
700 | 1 | a Sampson, A. T.4 aut |
700 | 1 | a Hughes, K.4 aut |
700 | 1 | a Bolton, I. A. G.4 aut |
700 | 1 | a Gori, K.4 aut |
700 | 1 | a Wang, J. H.4 aut |
700 | 1 | a Airikkala-Otter, I.4 aut |
700 | 1 | a Allen, J. L.4 aut |
700 | 1 | a Allum, K. M.4 aut |
700 | 1 | a Arnold, C. L.4 aut |
700 | 1 | a Bansse-Issa, L.4 aut |
700 | 1 | a Bhutia, T. N.4 aut |
700 | 1 | a Bisson, J. L.4 aut |
700 | 1 | a Blank, K.4 aut |
700 | 1 | a Briceno, C.4 aut |
700 | 1 | a Domracheva, A. C.4 aut |
700 | 1 | a Corrigan, A. M.4 aut |
700 | 1 | a Cran, H. R.4 aut |
700 | 1 | a Crawford, J. T.4 aut |
700 | 1 | a Cutter, S. M.4 aut |
700 | 1 | a Davis, E.4 aut |
700 | 1 | a de Castro, K. F.4 aut |
700 | 1 | a De Nardi, A. B.4 aut |
700 | 1 | a de Vos, A. P.4 aut |
700 | 1 | a Keena, L. D.4 aut |
700 | 1 | a Donelan, E. M.4 aut |
700 | 1 | a Huerta, A. R. E.4 aut |
700 | 1 | a Faramade, I. A.4 aut |
700 | 1 | a Fazil, M.4 aut |
700 | 1 | a Fotopoulou, E.4 aut |
700 | 1 | a Fruean, S. N.4 aut |
700 | 1 | a Gallardo-Arrieta, F.4 aut |
700 | 1 | a Glebova, O.4 aut |
700 | 1 | a Gouletsou, P. G.4 aut |
700 | 1 | a Hafelin Manrique, R. F.4 aut |
700 | 1 | a Henriques, Jjgp4 aut |
700 | 1 | a Horta, R. S.4 aut |
700 | 1 | a Ignatenko, N.4 aut |
700 | 1 | a Kane, Y.4 aut |
700 | 1 | a King, C.4 aut |
700 | 1 | a Koenig, D.4 aut |
700 | 1 | a Krupa, A.4 aut |
700 | 1 | a Kruzeniski, S. J.4 aut |
700 | 1 | a Lanza-Perea, M.4 aut |
700 | 1 | a Lazyan, M.4 aut |
700 | 1 | a Quintana, A. M. L.4 aut |
700 | 1 | a Losfelt, T.4 aut |
700 | 1 | a Marino, G.4 aut |
700 | 1 | a Martinez Castaneda, S.4 aut |
700 | 1 | a Martinez-Lopez, M. F.4 aut |
700 | 1 | a Masuruli, B. M.4 aut |
700 | 1 | a Meyer, M.4 aut |
700 | 1 | a Migneco, E. J.4 aut |
700 | 1 | a Nakanwagi, B.4 aut |
700 | 1 | a Neal, K. B.4 aut |
700 | 1 | a Neunzig, W.4 aut |
700 | 1 | a Nixon, S. J.4 aut |
700 | 1 | a Ortega-Pacheco, A.4 aut |
700 | 1 | a Pedraza-Ordonez, F.4 aut |
700 | 1 | a Peleteiro, M. C.4 aut |
700 | 1 | a Polak, K.4 aut |
700 | 1 | a Pye, R. J.4 aut |
700 | 1 | a Ramirez-Ante, J. C.4 aut |
700 | 1 | a Reece, J. F.4 aut |
700 | 1 | a Gutierrez, J. R.4 aut |
700 | 1 | a Sadia, H.4 aut |
700 | 1 | a Schmeling, S. K.4 aut |
700 | 1 | a Shamanova, O.4 aut |
700 | 1 | a Sherlock, A. G.4 aut |
700 | 1 | a Steenland-Smit, A. E.4 aut |
700 | 1 | a Svitich, A.4 aut |
700 | 1 | a Tapia Martinez, L. J.4 aut |
700 | 1 | a Ngoka, I. T.4 aut |
700 | 1 | a Torres, C. G.4 aut |
700 | 1 | a Tudor, E. M.4 aut |
700 | 1 | a van der Wel, M. G.4 aut |
700 | 1 | a Vitalaru, B. A.4 aut |
700 | 1 | a Vural, S. A.4 aut |
700 | 1 | a Walkinton, O.4 aut |
700 | 1 | a Wehrle-Martinez, A. S.4 aut |
700 | 1 | a Widdowson, S. A. E.4 aut |
700 | 1 | a Zvarich, I.4 aut |
700 | 1 | a Chinnery, P. F.4 aut |
700 | 1 | a Falkenberg, M.4 aut |
700 | 1 | a Gustafsson, C. M.4 aut |
700 | 1 | a Murchison, E. P.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 11q 11x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-020-16765-w.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/294859 |
856 | 4 8 | u https://doi.org/10.1038/s41467-020-16765-w |
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