Search: WFRF:(Taussig Mike)
> (2020-2021) >
Complex Autoantibod...
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain Injury.
-
Needham, Edward J (author)
-
Stoevesandt, Oda (author)
-
- Thelin, Eric P (author)
- Karolinska Institutet
-
show more...
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Zanier, Elisa R (author)
-
- Al Nimer, Faiez (author)
- Karolinska Institutet
-
- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Outtrim, Joanne G (author)
-
Newcombe, Virginia F J (author)
-
Mousa, Hani S (author)
-
- Simrén, Joel, 1996 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Yang, Zhihui (author)
-
Hutchinson, Peter J (author)
-
- Piehl, Fredrik (author)
- Karolinska Institutet
-
Helmy, Adel E (author)
-
Taussig, Mike J (author)
-
Wang, Kevin K W (author)
-
Jones, Joanne L (author)
-
Menon, David K (author)
-
Coles, Alasdair J (author)
-
show less...
-
(creator_code:org_t)
- 2021-07-01
- 2021
- English.
-
In: Journal of immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 207:1, s. 90-100
- Related links:
-
https://discovery.uc...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.4...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Most of the variation in outcome following severe traumatic brain injury (TBI) remains unexplained by currently recognized prognostic factors. Neuroinflammation may account for some of this difference. We hypothesized that TBI generated variable autoantibody responses between individuals that would contribute to outcome. We developed a custom protein microarray to detect autoantibodies to both CNS and systemic Ags in serum from the acute-phase (the first 7 d), late (6-12 mo), and long-term (6-13 y) intervals after TBI in human patients. We identified two distinct patterns of immune response to TBI. The first was a broad response to the majority of Ags tested, predominantly IgM mediated in the acute phase, then IgG dominant at late and long-term time points. The second was responses to specific Ags, most frequently myelin-associated glycopeptide (MAG), which persisted for several months post-TBI but then subsequently resolved. Exploratory analyses suggested that patients with a greater acute IgM response experienced worse outcomes than predicted from current known risk factors, suggesting a direct or indirect role in worsening outcome. Furthermore, late persistence of anti-MAG IgM autoantibodies correlated with raised serum neurofilament light concentrations at these time points, suggesting an association with ongoing neurodegeneration over the first year postinjury. Our results show that autoantibody production occurs in some individuals following TBI, can persist for many years, and is associated with worse patient outcome. The complexity of responses means that conventional approaches based on measuring responses to single antigenic targets may be misleading.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Needham, Edward ...
-
Stoevesandt, Oda
-
Thelin, Eric P
-
Zetterberg, Henr ...
-
Zanier, Elisa R
-
Al Nimer, Faiez
-
show more...
-
Ashton, Nicholas ...
-
Outtrim, Joanne ...
-
Newcombe, Virgin ...
-
Mousa, Hani S
-
Simrén, Joel, 19 ...
-
Blennow, Kaj, 19 ...
-
Yang, Zhihui
-
Hutchinson, Pete ...
-
Piehl, Fredrik
-
Helmy, Adel E
-
Taussig, Mike J
-
Wang, Kevin K W
-
Jones, Joanne L
-
Menon, David K
-
Coles, Alasdair ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Journal of immun ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet