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Sökning: WFRF:(Tengvall Pentti) > (2010-2014) > A bisphosphonate-co...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03745naa a2200457 4500 | |
| 001 | oai:DiVA.org:liu-77527 | |
| 003 | SwePub | |
| 008 | 120522s2012 | |||||||||||000 ||eng| | |
| 009 | oai:gup.ub.gu.se/160765 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-775272 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bone.2012.02.0012 DOI |
| 024 | 7 | a https://gup.ub.gu.se/publication/1607652 URI |
| 040 | a (SwePub)liud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Abtahi, Jahanu Östergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US4 aut0 (Swepub:liu)jahab31 |
| 245 | 1 0 | a A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants |
| 264 | 1 | b Elsevier,c 2012 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|Swedish Research Council|VR 2009-6725| | |
| 520 | a Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6 months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p = 0.0001; Cohens d = 1.3). The average difference in increase in ISQ and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2 months (p = 0.012) and at 6 months (p = 0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng |
| 653 | a Bone healing | |
| 653 | a Dental implant | |
| 653 | a Drug delivery | |
| 653 | a Mechanical test | |
| 653 | a Osseointegration bisphosphonates | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Tengvall, Penttiu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials4 aut0 (Swepub:gu)xtenpe |
| 700 | 1 | a Aspenberg, Peru Linköpings universitet,Östergötlands Läns Landsting,Ortopedkliniken i Linköping,Ortopedi,Hälsouniversitetet4 aut0 (Swepub:liu)peras36 |
| 710 | 2 | a Linköpings universitetb Ortopedi4 org |
| 773 | 0 | t Boned : Elsevierg 50:5, s. 1148-1151q 50:5<1148-1151x 8756-3282x 1873-2763 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:528606/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint |
| 856 | 4 | u http://liu.diva-portal.org/smash/get/diva2:528606/FULLTEXT01 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77527 |
| 856 | 4 8 | u https://doi.org/10.1016/j.bone.2012.02.001 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/160765 |
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