Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study

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Fältnamn	Indikatorer	Metadata
000		09830naa a2201309 4500
001		oai:DiVA.org:liu-163483
003		SwePub
008		200217s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1634832 URI
024	7	a https://doi.org/10.1093/ijnp/pyz0532 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fountoulakis, Konstantinos N.u Aristotle Univ Thessaloniki, Greece4 aut
245	1 0	a Staging of Schizophrenia With the Use of PANSS :b An International Multi-Center Study
264		c 2019-09-30
264	1	b Oxford University Press,c 2019
338		a electronic2 rdacarrier
500		a Funding Agencies\|NHMRC Senior Principal Research FellowshipNational Health and Medical Research Council of Australia [APP1059660, APP1156072]
520		a IntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.MethodsTwenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.ResultsExploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.DiscussionThis study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a illness course; outcome; schizophrenia; staging
700	1	a Dragioti, Elena,c Ph.D.u Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden4 aut0 (Swepub:liu)eledr71
700	1	a Theofilidis, Antonis T.u Aristotle Univ Thessaloniki, Greece4 aut
700	1	a Wiklund, Tobias,d 1986-u Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden4 aut0 (Swepub:liu)tobwi28
700	1	a Atmatzidis, Xenofonu Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Karolinska Huddinge Univ Hosp, Sweden4 aut0 (Swepub:liu)n/a
700	1	a Nimatoudis, Ioannisu Aristotle Univ Thessaloniki, Greece4 aut
700	1	a Thys, Eriku Katholieke Univ Leuven, Belgium; KU, Belgium4 aut
700	1	a Wampers, Martienu Katholieke Univ Leuven, Belgium; KU, Belgium4 aut
700	1	a Hranov, Luchezaru Univ Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria4 aut
700	1	a Hristova, Trayanau Univ Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria4 aut
700	1	a Aptalidis, Daniilu Univ Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria4 aut
700	1	a Milev, Roumenu Queens Univ, Canada4 aut
700	1	a Iftene, Feliciau Queens Univ, Canada4 aut
700	1	a Spaniel, Filipu Natl Inst Mental Hlth, Czech Republic4 aut
700	1	a Knytl, Pavelu Natl Inst Mental Hlth, Czech Republic4 aut
700	1	a Furstova, Petrau Natl Inst Mental Hlth, Czech Republic4 aut
700	1	a From, Tiinau Univ Turku, Finland4 aut
700	1	a Karlsson, Henryu Univ Turku, Finland4 aut
700	1	a Walta, Maijau Univ Turku, Finland4 aut
700	1	a Salokangas, Raimo K. R.u Univ Turku, Finland4 aut
700	1	a Azorin, Jean-Michelu St Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France4 aut
700	1	a Bouniard, Justineu St Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France4 aut
700	1	a Montant, Julieu St Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France4 aut
700	1	a Juckel, Georgu Ruhr Univ Bochum, Germany4 aut
700	1	a Haussleiter, Ida S.u Ruhr Univ Bochum, Germany4 aut
700	1	a Douzenis, Athanasiosu Univ Athens, Greece4 aut
700	1	a Michopoulos, Ioannisu Univ Athens, Greece4 aut
700	1	a Ferentinos, Panagiotisu Univ Athens, Greece4 aut
700	1	a Smyrnis, Nikolaosu Univ Athens, Greece4 aut
700	1	a Mantonakis, Leonidasu Univ Athens, Greece4 aut
700	1	a Nemes, Zsofiau Nyiro Gyula Hosp, Hungary4 aut
700	1	a Gonda, Xeniau Semmelweis Univ, Hungary4 aut
700	1	a Vajda, Dorau Semmelweis Univ, Hungary4 aut
700	1	a Juhasz, Anitau Semmelweis Univ, Hungary4 aut
700	1	a Shrivastava, Amreshu Western Univ, Canada4 aut
700	1	a Waddington, Johnu Royal Coll Surgeons Ireland, Ireland4 aut
700	1	a Pompili, Mauriziou Sapienza Univ Rome, Italy4 aut
700	1	a Comparelli, Annau Sapienza Univ Rome, Italy4 aut
700	1	a Corigliano, Valentinau Sapienza Univ Rome, Italy4 aut
700	1	a Rancans, Elmarsu Riga Stradins Univ, Latvia4 aut
700	1	a Navickas, Alvydasu Vilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania4 aut
700	1	a Hilbig, Janu Vilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania4 aut
700	1	a Bukelskis, Laurynasu Vilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania4 aut
700	1	a Stevovic, Lidija Injacu Clin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro4 aut
700	1	a Vodopic, Sanjau Clin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro4 aut
700	1	a Esan, Oluyomiu Univ Ibadan, Nigeria4 aut
700	1	a Oladele, Oluremiu Univ Ibadan, Nigeria4 aut
700	1	a Osunbote, Christopheru Univ Ibadan, Nigeria4 aut
700	1	a Rybakowski, Janusz K.u Poznan Univ Med Sci, Poland4 aut
700	1	a Wojciak, Pawelu Poznan Univ Med Sci, Poland4 aut
700	1	a Domowicz, Klaudiau Poznan Univ Med Sci, Poland4 aut
700	1	a Figueira, Maria Luisau Santa Maria Univ Hosp, Portugal4 aut
700	1	a Linhares, Ludgerou Santa Maria Univ Hosp, Portugal4 aut
700	1	a Crawford, Joanau Santa Maria Univ Hosp, Portugal4 aut
700	1	a Panfil, Anca-Liviau Univ Med and Pharm Targu Mures, Romania4 aut
700	1	a Smirnova, Dariau Samara State Med Univ, Russia4 aut
700	1	a Izmailova, Olgau Samara State Med Univ, Russia4 aut
700	1	a Lecic-Tosevski, Dusicau Inst Mental Hlth, Serbia; Serbian Acad Arts and Sci, Serbia4 aut
700	1	a Temmingh, Henku Univ Cape Town, South Africa4 aut
700	1	a Howells, Fleuru Univ Cape Town, South Africa4 aut
700	1	a Bobes, Juliou Univ Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain4 aut
700	1	a Garcia-Portilla, Maria Pazu Univ Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain4 aut
700	1	a Garcia-Alvarez, Leticiau Univ Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain4 aut
700	1	a Erzin, Gamzeu Diskapi Yildirim Beyazit Training and Res Hosp, Turkey4 aut
700	1	a Karadag, Hasanu Diskapi Yildirim Beyazit Training and Res Hosp, Turkey4 aut
700	1	a De Sousa, Avinashu Lokmanya Tilak Municipal Gen Hosp and Med Coll, India4 aut
700	1	a Bendre, Anujau Lokmanya Tilak Municipal Gen Hosp and Med Coll, India4 aut
700	1	a Hoschl, Cyrilu Natl Inst Mental Hlth, Czech Republic4 aut
700	1	a Bredicean, Cristinau Univ Med and Farm Timisoara, Romania4 aut
700	1	a Papava, Ionu Univ Med and Farm Timisoara, Romania4 aut
700	1	a Vukovic, Oliverau Univ Belgrade, Serbia4 aut
700	1	a Pejuskovic, Bojanau Royal Coll Surgeons Ireland, Ireland4 aut
700	1	a Russell, Vincentu Royal Coll Surgeons Ireland, Ireland4 aut
700	1	a Athanasiadis, Loukasu Aristotle Univ Thessaloniki, Greece4 aut
700	1	a Konsta, Anastasiau Aristotle Univ Thessaloniki, Greece4 aut
700	1	a Stein, Danu Univ Cape Town, South Africa4 aut
700	1	a Berk, Michaelu Deakin Univ, Australia; Orygen, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia4 aut
700	1	a Dean, Oliviau Deakin Univ, Australia4 aut
700	1	a Tandon, Rajivu Univ Florida, FL 32611 USA4 aut
700	1	a Kasper, Siegfriedu Med Univ Vienna, Austria4 aut
700	1	a De Hert, Marcu Katholieke Univ Leuven, Belgium; KU, Belgium4 aut
710	2	a Aristotle Univ Thessaloniki, Greeceb Avdelningen för samhällsmedicin4 org
773	0	t International Journal of Neuropsychopharmacologyd : Oxford University Pressg 22:11, s. 681-697q 22:11<681-697x 1461-1457x 1469-5111
856	4	u https://doi.org/10.1093/ijnp/pyz053y Fulltext
856	4	u https://liu.diva-portal.org/smash/get/diva2:1393663/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://academic.oup.com/ijnp/article-pdf/22/11/681/31081742/pyz053.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163483
856	4 8	u https://doi.org/10.1093/ijnp/pyz053

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Av författaren/redakt...: Fountoulakis, Ko ...; Dragioti, Elena, ...; Theofilidis, Ant ...; Wiklund, Tobias, ...; Atmatzidis, Xeno ...; Nimatoudis, Ioan ...; visa fler...; Thys, Erik; Wampers, Martien; Hranov, Luchezar; Hristova, Trayan ...; Aptalidis, Danii ...; Milev, Roumen; Iftene, Felicia; Spaniel, Filip; Knytl, Pavel; Furstova, Petra; From, Tiina; Karlsson, Henry; Walta, Maija; Salokangas, Raim ...; Azorin, Jean-Mic ...; Bouniard, Justin ...; Montant, Julie; Juckel, Georg; Haussleiter, Ida ...; Douzenis, Athana ...; Michopoulos, Ioa ...; Ferentinos, Pana ...; Smyrnis, Nikolao ...; Mantonakis, Leon ...; Nemes, Zsofia; Gonda, Xenia; Vajda, Dora; Juhasz, Anita; Shrivastava, Amr ...; Waddington, John; Pompili, Maurizi ...; Comparelli, Anna; Corigliano, Vale ...; Rancans, Elmars; Navickas, Alvyda ...; Hilbig, Jan; Bukelskis, Laury ...; Stevovic, Lidija ...; Vodopic, Sanja; Esan, Oluyomi; Oladele, Oluremi; Osunbote, Christ ...; Rybakowski, Janu ...; Wojciak, Pawel; Domowicz, Klaudi ...; Figueira, Maria ...; Linhares, Ludger ...; Crawford, Joana; Panfil, Anca-Liv ...; Smirnova, Daria; Izmailova, Olga; Lecic-Tosevski, ...; Temmingh, Henk; Howells, Fleur; Bobes, Julio; Garcia-Portilla, ...; Garcia-Alvarez, ...; Erzin, Gamze; Karadag, Hasan; De Sousa, Avinas ...; Bendre, Anuja; Hoschl, Cyril; Bredicean, Crist ...; Papava, Ion; Vukovic, Olivera; Pejuskovic, Boja ...; Russell, Vincent; Athanasiadis, Lo ...; Konsta, Anastasi ...; Stein, Dan; Berk, Michael; Dean, Olivia; Tandon, Rajiv; Kasper, Siegfrie ...; De Hert, Marc; visa färre...

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