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Sökning: WFRF:(Thorek Daniel L J) > Improved 223Ra Ther...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004528naa a2200553 4500
001oai:lup.lub.lu.se:7052b1f3-523c-4668-8f59-c3ce8ff21e36
003SwePub
008220614s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/7052b1f3-523c-4668-8f59-c3ce8ff21e362 URI
0247 a https://doi.org/10.2967/jnumed.121.2619772 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Abou, Diane S.u Washington University in St. Louis4 aut
2451 0a Improved 223Ra Therapy with Combination Epithelial Sodium Channel Blockade
264 c 2021-04-09
264 1b Society of Nuclear Medicine,c 2021
300 a 8 s.
520 a [223Ra]RaCl2 is the first approved a-particle-emitting therapy and is indicated for treatment of bonemetastatic castration-resistant prostate cancer. Approximately half the dose is absorbed into the gastrointestinal tract within minutes of administration, limiting disease-site uptake and contributing to toxicity. Here,we investigated the role of enteric ion channels and their modulation for improved therapeutic efficacy and reduced side effects. Methods: Using primary human duodenal organoids (enteroids) asin vitromodelsof the functionalgastrointestinal epithelium, we found that amiloride (epithelial sodium ion channel blocker) and NS-1619 (K+ channel activator) presented significant effects in 223Ramembranal transport.Radioactivedrugdistributionwas evaluated for lead combinations in vivo and in osteosarcoma and prostate cancermodels.Results:Amiloride shifted 223Ra uptake in vivo fromthe gut and nearly doubled the uptake at sites of bone remodeling. Bone tumor growth inhibition with the combination as measured by bioluminescent imaging and radiographywas significantly greater than that with single agents alone, and the combination resulted in noweight loss.Conclusion: This combination of approved agentsmay readily be implemented as a clinical approach to improve the outcomes of bonemetastatic cancer patients with the benefit of ameliorated tolerability. COPYRIGHT
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a Ra
653 a amiloride
653 a bone
653 a gastrointestinal
653 a ion channel
7001 a Fears, Amanda4 aut
7001 a Summer, Lucy4 aut
7001 a Longtine, Mark4 aut
7001 a Benabdallah, Nadiau Washington University in St. Louis4 aut
7001 a Riddle, Ryan C.u Johns Hopkins University,Baltimore Veterans Administration Medical Center4 aut
7001 a Ulmert, Davidu Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, Los Angeles4 aut0 (Swepub:lu)klke-dul
7001 a Michalski, Jeff M.u Washington University in St. Louis4 aut
7001 a Wahl, Richard L.4 aut
7001 a Chesner, Deniseu Johns Hopkins University School of Medicine4 aut
7001 a Doucet, Micheleu Johns Hopkins University School of Medicine4 aut
7001 a Zachos, Nicholas C.u Johns Hopkins University School of Medicine4 aut
7001 a Simons, Brian W.u Baylor College of Medicine4 aut
7001 a Thorek, Daniel L.J.u Washington University in St. Louis4 aut
7102 a Washington University in St. Louisb Johns Hopkins University4 org
7730 t Journal of Nuclear Medicined : Society of Nuclear Medicineg 62:12, s. 1751-1758q 62:12<1751-1758x 0161-5505x 2159-662X
8564 u http://dx.doi.org/10.2967/jnumed.121.261977x freey FULLTEXT
8564 u https://jnm.snmjournals.org/content/jnumed/early/2021/04/09/jnumed.121.261977.full.pdf
8564 8u https://lup.lub.lu.se/record/7052b1f3-523c-4668-8f59-c3ce8ff21e36
8564 8u https://doi.org/10.2967/jnumed.121.261977

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