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Platelet-derived gr...
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Nikkhah, GSkåne University Hospital
(författare)
Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture
- Artikel/kapitelEngelska1993
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:b965dfa5-eda2-4ffc-814e-69b1fe285368
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https://lup.lub.lu.se/record/1107589URI
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https://doi.org/10.1007/BF00229041DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197017URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The effect of two isoforms of platelet-derived growth factor (PDGF), PDGF-AA and PDGF-BB, was tested on dissociated cell cultures of ventral mesencephalon from rat and human embryos. PDGF-BB but not PDGF-AA reduced the progressive loss of tyrosine hydroxylase- (TH)-positive neurons in rat and human cell cultures. The mean number of TH-positive cells in the PDGF-BB-treated rat culture was 64% and 106% higher than in the control cultures after 7 and 10 days in vitro, respectively. Corresponding figures for human TH-positive neurons were 90% and 145%. The influence of PDGF-BB was specific for TH-positive neurons and not a general trophic effect, since no change of either total cell number or metabolic activity was found. In PDGF-BB-treated cultures of human but not rat tissue the TH-positive neurons had longer neurites than observed in control or PDGF-AA-treated cultures. These data indicate that PDGF-BB may act as a trophic factor for mesencephalic dopaminergic neurons and suggest that administration of PDGF-BB could ameliorate degeneration and possibly promote axonal sprouting of these neurons in vivo.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Odin, PerLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-poi
(författare)
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Smits, AUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)anjasmit
(författare)
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Tingström, AndersUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:lu)mpu-ati
(författare)
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Sanmartin, AgnetaLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-as4
(författare)
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Brundin, PatrikLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine,Skåne University Hospital(Swepub:lu)mphy-pbr
(författare)
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Funa, KUppsala universitet,Ludwiginstitutet för cancerforskning
(författare)
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Lindvall, OlleLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)neur-oli
(författare)
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Othberg, A
(författare)
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Skåne University HospitalNeurologi, Lund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Experimental Brain Research92:3, s. 516-5230014-48191432-1106
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