WFRF:(Tufveson G.)
Sökning: WFRF:(Tufveson G.) > (2020) > Targeting CXCR1/2 D...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06197naa a2200781 4500 | |
| 001 | oai:gup.ub.gu.se/292433 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-409674 | |
| 009 | oai:prod.swepub.kib.ki.se:143241199 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2924332 URI |
| 024 | 7 | a https://doi.org/10.2337/dc19-14802 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4096742 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1432411992 URI |
| 040 | a (SwePub)gud (SwePub)uud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Maffi, P.u IRCCS Osped San Raffaele, San Raffaele Diabet Res Inst, Milan, Italy4 aut |
| 245 | 1 0 | a Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes |
| 264 | c 2020-02-04 | |
| 264 | 1 | b American Diabetes Association,c 2020 |
| 520 | a OBJECTIVE Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS A phase 3, multicenter, randomized, double-blind, parallel-assignment study () was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition to immunosuppression. Primary outcome was the area under the curve (AUC) for C-peptide during the mixed-meal tolerance test at day 75 +/- 5 after the first and day 365 +/- 14 after the last transplant. Secondary end points included insulin independence and standard measures of glycemic control. RESULTS The intention-to-treat analysis did not show a significant difference in C-peptide AUC at both day 75 (27 on reparixin vs. 18 on placebo, P = 0.99) and day 365 (24 on reparixin vs. 15 on placebo, P = 0.71). There was no statistically significant difference between treatment groups at any time point for any secondary variable. Analysis of patient subsets showed a trend for a higher percentage of subjects retaining insulin independence for 1 year after a single islet infusion in patients receiving reparixin as compared with patients receiving placebo (26.7% vs. 0%, P = 0.09) when antithymocyte globulin was used as induction immunosuppression. CONCLUSIONS In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a beta-cell function | |
| 653 | a antiinflammatory strategies | |
| 653 | a inhibition | |
| 653 | a induction | |
| 653 | a immunosuppression | |
| 653 | a engraftment | |
| 653 | a survival | |
| 653 | a regimen | |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Lundgren, T.u Karolinska Institutet4 aut |
| 700 | 1 | a Tufveson, Gunnaru Uppsala universitet,Transplantationskirurgi4 aut0 (Swepub:uu)gutuf839 |
| 700 | 1 | a Rafael, E.u Skane Univ Hosp, Malmo, Sweden4 aut |
| 700 | 1 | a Shaw, J. A. M.u Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England;Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England,IRCCS Osped San Raffaele, Milan, Italy4 aut |
| 700 | 1 | a Liew, A.u Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England;Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England4 aut |
| 700 | 1 | a Saudek, F.u Inst Clin & Expt Med, Prague, Czech Republic4 aut |
| 700 | 1 | a Witkowski, P.u Univ Chicago Med, Transplantat Inst, Chicago, IL USA4 aut |
| 700 | 1 | a Golab, K.u Univ Chicago Med, Transplantat Inst, Chicago, IL USA4 aut |
| 700 | 1 | a Bertuzzi, F.u Osped Niguarda Ca Granda, Milan, Italy4 aut |
| 700 | 1 | a Gustafsson, Bengt,d 1946u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Univ Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xgbenk |
| 700 | 1 | a Daffonchio, L.u Dompe Farmaceut SpA, Dept Res & Dev, Milan, Italy4 aut |
| 700 | 1 | a Ruffini, P. A.u Dompe Farmaceut SpA, Dept Res & Dev, Milan, Italy4 aut |
| 700 | 1 | a Piemonti, L.u IRCCS Osped San Raffaele, San Raffaele Diabet Res Inst, Milan, Italy4 aut |
| 700 | 1 | a Nano, R.u IRCCS Osped San Raffaele, Milan, Italy4 aut |
| 700 | 1 | a Mercalli, A.4 aut |
| 700 | 1 | a Lampasona, V.u IRCCS Osped San Raffaele, Milan, Italy4 aut |
| 700 | 1 | a Magistretti, P.u IRCCS Osped San Raffaele, Milan, Italy4 aut |
| 700 | 1 | a Sordi, V.u IRCCS Osped San Raffaele, Milan, Italy4 aut |
| 700 | 1 | a Antonio, S.u IRCCS Osped San Raffaele, Milan, Italy4 aut |
| 700 | 1 | a Antonioli, B.u Osped Niguarda Ca Granda, Milan, Italy4 aut |
| 700 | 1 | a Galuzzi, M.u Osped Niguarda Ca Granda, Milan, Italy4 aut |
| 700 | 1 | a Tosca, M. C.u Osped Niguarda Ca Granda, Milan, Italy4 aut |
| 700 | 1 | a De Carlis, L.u Osped Niguarda Ca Granda, Milan, Italy4 aut |
| 700 | 1 | a Colussi, G.u Osped Niguarda Ca Granda, Milan, Italy4 aut |
| 700 | 1 | a Korsgren, Olleu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)ollekors |
| 700 | 1 | a Pollard, H.u Skane Univ Hosp, Malmo, Sweden4 aut |
| 710 | 2 | a Karolinska Institutetb IRCCS Osped San Raffaele, San Raffaele Diabet Res Inst, Milan, Italy4 org |
| 773 | 0 | t Diabetes Cared : American Diabetes Associationg 43:4, s. 710-718q 43:4<710-718x 0149-5992x 1935-5548 |
| 856 | 4 | u https://care.diabetesjournals.org/content/diacare/43/4/710.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/292433 |
| 856 | 4 8 | u https://doi.org/10.2337/dc19-1480 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409674 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143241199 |
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