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Sökning: WFRF:(Uiterwaal Cuno S P M) > (2014) > Coffee and tea cons...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007127naa a2201081 4500
001oai:lup.lub.lu.se:73011e4a-ec91-4c36-9c08-249e50996c89
003SwePub
008160401s2014 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-84217
009oai:prod.swepub.kib.ki.se:129043865
0247 a https://lup.lub.lu.se/record/45586582 URI
0247 a https://doi.org/10.1002/ijc.286552 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-842172 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1290438652 URI
040 a (SwePub)lud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dik, Vincent K.4 aut
2451 0a Coffee and tea consumption, genotype- based CYP1A2 and NAT2 activity and colorectal cancer risk- Results from the EPIC cohort study
264 c 2013-12-21
264 1b Wiley,c 2014
520 a Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992-2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. After a median follow-up of 11.6 years, 4,234 participants developed CRC (mean age 64.78.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95-1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97-1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84-1.11) and tea (HR 0.97, 95% CI 0.86-1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC. What's new? Coffee and tea contain numerous compounds that may protect against colorectal cancer (CRC). In this study of more than 475,000 participants over more than a decade, the authors investigated whether coffee or tea consumption is associated with an altered risk of developing CRC. They also asked whether genetic variations in two enzymes involved in caffeine metabolism (CYP1A2 and NAT2) might affect this risk. They conclude that neither consumption patterns, nor genetic differences in caffeine metabolism, appear to have a significant impact on CRC risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Colorectal cancer
653 a coffee
653 a tea
653 a CYP1A2
653 a NAT2
7001 a Bueno-de-Mesquita, H. B(as)4 aut
7001 a Van Oijen, Martijn G. H.4 aut
7001 a Siersema, Peter D.4 aut
7001 a Uiterwaal, Cuno S. P. M.4 aut
7001 a Van Gils, Carla H.4 aut
7001 a Van Duijnhoven, Fraenzel J. B.4 aut
7001 a Cauchi, Stephane4 aut
7001 a Yengo, Loic4 aut
7001 a Froguel, Philippe4 aut
7001 a Overvad, Kim4 aut
7001 a Bech, Bodil H.4 aut
7001 a Tjonneland, Anne4 aut
7001 a Olsen, Anja4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Racine, Antoine4 aut
7001 a Fagherazzi, Guy4 aut
7001 a Kuehn, Tilman4 aut
7001 a Campa, Daniele4 aut
7001 a Boeing, Heiner4 aut
7001 a Aleksandrova, Krasimira4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Peppa, Eleni4 aut
7001 a Oikonomou, Eleni4 aut
7001 a Palli, Domenico4 aut
7001 a Grioni, Sara4 aut
7001 a Vineis, Paolo4 aut
7001 a Tumino, Rosaria4 aut
7001 a Panico, Salvatore4 aut
7001 a Peeters, Petra H. M.4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Engeset, Dagrun4 aut
7001 a Braaten, Tonje4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Chirlaque, Maria-Doloresu nutrition4 aut
7001 a Sanchez, Maria-Jose4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Zamora-Ros, Raul4 aut
7001 a Argueelles, Marcial4 aut
7001 a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji
7001 a Wallström, Peteru Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)pe6853wa
7001 a Nilsson, Lena Maria,d 1965-u Umeå universitet,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum)4 aut0 (Swepub:umu)leni0002
7001 a Ljuslinder, Ingridu Umeå universitet,Onkologi,Arktiskt centrum vid Umeå universitet (Arcum)4 aut0 (Swepub:umu)inlj0001
7001 a Travis, Ruth C.4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Freisling, Heinz4 aut
7001 a Licaj, Idlir4 aut
7001 a Jenab, Mazda4 aut
7001 a Gunter, Marc J.4 aut
7001 a Murphy, Neil4 aut
7001 a Romaguera-Bosch, Dora4 aut
7001 a Riboli, Elio4 aut
7102 a Karolinska Institutetb nutrition4 org
7730 t International Journal of Cancerd : Wileyg 135:2, s. 401-412q 135:2<401-412x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.28655y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28655
8564 8u https://lup.lub.lu.se/record/4558658
8564 8u https://doi.org/10.1002/ijc.28655
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84217
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:129043865

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