Tyck till om SwePub Sök här!
WFRF:(Ullen Anders)
Sökning: WFRF:(Ullen Anders) > Göteborgs universitet > Gudbjartsson Tomas > Recombinant factor ...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Recombinant factor VIIa use in acute type A aortic dissection repair : A multicenter propensity-score-matched report from the Nordic Consortium for Acute Type A Aortic Dissection
-
- Zindovic, Igor (författare)
- Lund University,Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Forskargrupper vid Lunds universitet,Bleeding disorders and acute typ-A dissection,Lund University Research Groups,Skåne University Hospital
-
- Sjögren, Johan (författare)
- Lund University,Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Forskargrupper vid Lunds universitet,Bleeding disorders and acute typ-A dissection,Lund University Research Groups,Skåne University Hospital
-
- Ahlsson, Anders (författare)
- Karolinska Institutet
- visa fler...
- visa färre...
- (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
- Ingår i: Journal of Thoracic and Cardiovascular Surgery. - : Elsevier BV. - 0022-5223 .- 1097-685X. ; 154:6, s. 2-1859
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: Surgery for acute type A aortic dissection (ATAAD) is often complicated by excessive bleeding. Recombinant factor VIIa (rFVIIa) effectively treats refractory bleeding associated with ATAAD surgery; however, adverse effects of rFVIIa in these patients have not been fully assessed. Here we evaluated rFVIIa treatment in ATAAD surgery using the Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD) database. Methods: This was a multicenter, propensity score-matched, retrospective study. Information about rFVIIa use was available for 761 patients, of whom 171 were treated with rFVIIa. We successfully matched 120 patients treated with rFVIIa with 120 controls. Primary endpoints were in-hospital mortality, postoperative stroke, and renal replacement therapy (RRT). Survival data were presented using Kaplan-Meier estimates. Results: Compared with controls, patients treated with rFVIIa received more transfusions of packed red blood cells (median, 9.0 U [4.0-17.0 U] vs 5.0 U [2.0-11.0 U]; P = .008), platelets (4.0 U [2.0-8.0 U] vs 2.0 U [1.0-4.4 U]; P <.001), and fresh frozen plasma (8.0 U [4.0-18.0 U] vs 5.5 U [2.0-10.3 U]; P = .01) underwent reexploration for bleeding more often (31.0% vs 16.8%; P = .014); and had greater 24-hour chest tube output (1500 L [835-2500 mL] vs 990 mL [520-1720 mL]). Treatment with rFVIIa was not associated with significantly increased rates of in-hospital mortality (odds ratio [OR], 0.74; 95% confidence interval [CI], 0.34-1.55; P = .487), postoperative stroke (OR, 1.75; 95% CI, 0.82-3.91; P = .163), or RRT (OR, 1.18; 95% CI, 0.48-2.92; P = .839). Conclusions: In this propensity-matched cohort study of patients undergoing ATAAD surgery, treatment with rFVIIa for major bleeding was not associated with a significantly increased risk of stroke, RRT, or mortality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Aneurysm
- Aorta
- Dissecting
- Hemorrhage
- aorta; aneurysm; dissecting; hemorrhage
- ACTIVATED FACTOR-VII; CARDIOPULMONARY BYPASS; CARDIAC-SURGERY; MORTALITY
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
- Journal of Thoracic and Cardiovascular Surgery (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Zindovic, Igor
- Sjögren, Johan
- Ahlsson, Anders
- Bjursten, Henrik
- Fuglsang, Simon
- Geirsson, Arnar
- visa fler...
- Ingemansson, Ric ...
- Hansson, Emma C. ...
- Mennander, Ari
- Olsson, Christia ...
- Pan, Emily
- Ullén, Susann
- Gudbjartsson, To ...
- Nozohoor, Shahab
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Kardiologi
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- Artiklar i publikationen
- Journal of Thora ...
- Av lärosätet
- Lunds universitet
- Göteborgs universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
