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Sökning: WFRF:(Valarcher Jean Francois) > (2010-2014) > Characterization of...

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FältnamnIndikatorerMetadata
00005240naa a2200565 4500
001oai:DiVA.org:uu-229724
003SwePub
008140812s2014 | |||||||||||000 ||eng|
009oai:slubar.slu.se:64280
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2297242 URI
0247 a https://doi.org/10.1128/CVI.00162-142 DOI
0247 a https://res.slu.se/id/publ/642802 URI
040 a (SwePub)uud (SwePub)slu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hägglund, Sarau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)49235
2451 0a Characterization of an Experimental Vaccine for Bovine Respiratory Syncytial Virus
264 1c 2014
338 a print2 rdacarrier
520 a Bovine respiratory syncytial virus (BRSV) and human respiratory syncytial virus (HRSV) are major causes of respiratory disease in calves and children, respectively, and are priorities for vaccine development. We previously demonstrated that an experimental vaccine, BRSV-immunostimulating complex (ISCOM), is effective in calves with maternal antibodies. The present study focuses on the antigenic characterization of this vaccine for the design of new-generation subunit vaccines. The results of our study confirmed the presence of membrane glycoprotein (G), fusion glycoprotein (F), and nucleoprotein (N) proteins in the ISCOMs, and this knowledge was extended by the identification of matrix (M), M2-1, phosphoprotein (P), small hydrophobic protein (SH) and of cellular membrane proteins, such as the integrins alpha(V)beta(1), alpha(V)beta(3), and alpha(3)beta(1). The quantity of the major protein F was 4- to 5-fold greater than that of N (similar to 77 mu g versus similar to 17 mu g/calf dose), whereas G, M, M2-1, P, and SH were likely present in smaller amounts. The polymerase (L), M2-2, nonstructural 1 (NS1), and NS2 proteins were not detected, suggesting that they are not essential for protection. Sera from the BRSV-ISCOM-immunized calves contained high titers of IgG antibody specific for F, G, N, and SH. Antibody responses against M and P were not detected; however, this does not exclude their role in protective T-cell responses. The absence of immunopathological effects of the cellular proteins, such as integrins, needs to be further confirmed, and their possible contribution to adjuvant functions requires elucidation. This work suggests that a combination of several surface and internal proteins should be included in subunit RSV vaccines and identifies absent proteins as potential candidates for differentiating infected from vaccinated animals.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
650 7a LANTBRUKSVETENSKAPERx Veterinärmedicin0 (SwePub)4032 hsv//swe
650 7a AGRICULTURAL SCIENCESx Veterinary Science0 (SwePub)4032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a LANTBRUKSVETENSKAPERx Veterinärmedicinx Annan veterinärmedicin0 (SwePub)403042 hsv//swe
650 7a AGRICULTURAL SCIENCESx Veterinary Sciencex Other Veterinary Science0 (SwePub)403042 hsv//eng
7001 a Hu, Kefei4 aut
7001 a Blodörn, Kristeru Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)48694
7001 a Makabi-Panzu, Boby4 aut
7001 a Gaillard, Anne-Laure4 aut
7001 a Ellencrona, Karinu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)52708
7001 a Chevret, Didier4 aut
7001 a Hellman, Larsu Uppsala universitet,Kemisk biologi4 aut0 (Swepub:uu)larshell
7001 a Bengtsson, Karin Lovgren4 aut
7001 a Riffault, Sabine4 aut
7001 a Taylor, Geraldine4 aut
7001 a Valarcher, Jean-Francoisu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)50389
7001 a Eleouet, Jean-Francois4 aut
7102 a Sveriges lantbruksuniversitetb Institutionen för kliniska vetenskaper (KV)4 org
7102 a Sveriges lantbruksuniversitet
7730 t Clinical and Vaccine Immunologyg 21:7, s. 997-1004q 21:7<997-1004x 1556-6811x 1556-679X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229724
8564 8u https://doi.org/10.1128/CVI.00162-14
8564 8u https://res.slu.se/id/publ/64280

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