Search: WFRF:(Valle Timo T)
> (2015-2019) >
Clinical value of c...
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
-
- Meeter, Lieke H.H. (author)
- Erasmus University Medical Center
-
- Steketee, Rebecca M.E. (author)
- Erasmus University Medical Center
-
- Salkovic, Dina (author)
- Erasmus University Medical Center
-
show more...
-
- Vos, Maartje E. (author)
- Erasmus University Medical Center
-
- Grossman, Murray (author)
- University of Pennsylvania
-
- McMillan, Corey T. (author)
- University of Pennsylvania
-
- Irwin, David J. (author)
- University of Pennsylvania
-
- Boxer, Adam L. (author)
- University of California, San Francisco
-
- Rojas, Julio C. (author)
- University of California, San Francisco
-
- Olney, Nicholas T. (author)
- University of California, San Francisco
-
- Karydas, Anna (author)
- University of California, San Francisco
-
- Miller, Bruce L. (author)
- University of California, San Francisco
-
- Pijnenburg, Yolande A.L. (author)
- Vrije Universiteit Amsterdam
-
- Barkhof, Frederik (author)
- University College London
-
- Sánchez-Valle, Raquel (author)
- Hospital Clínic of Barcelona
-
- Lladó, Albert (author)
- Hospital Clínic of Barcelona
-
- Borrego-Ecija, Sergi (author)
- Hospital Clínic of Barcelona
-
- Diehl-Schmid, Janine (author)
- Technical University of Munich
-
- Grimmer, Timo (author)
- Technical University of Munich
-
- Goldhardt, Oliver (author)
- Technical University of Munich
-
- Santillo, Alexander F. (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
-
- Hansson, Oskar (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Klinisk minnesforskning,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Neurobiology,Lund University Research Groups,Clinical Memory Research,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research
-
- Vestberg, Susanne (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences
-
- Borroni, Barbara (author)
- University of Brescia
-
- Padovani, Alessandro (author)
- University of Brescia
-
- Galimberti, Daniela (author)
- University of Milan
-
- Scarpini, Elio (author)
- University of Milan
-
- Rohrer, Jonathan D. (author)
- University College London
-
- Woollacott, Ione O.C. (author)
- University College London
-
- Synofzik, Matthis (author)
- University of Tübingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
-
- Wilke, Carlo (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
-
- De Mendonca, Alexandre (author)
- University of Lisbon
-
- Vandenberghe, Rik (author)
- University Hospitals Leuven
-
- Benussi, Luisa (author)
- Centro San Giovanni di Dio Fatebenefratelli
-
- Ghidoni, Roberta (author)
- Centro San Giovanni di Dio Fatebenefratelli
-
- Binetti, Giuliano (author)
- Centro San Giovanni di Dio Fatebenefratelli
-
- Niessen, Wiro J. (author)
- Delft University of Technology
-
- Papma, Janne M. (author)
- Erasmus University Medical Center
-
- Seelaar, Harro (author)
- Erasmus University Medical Center
-
- Jiskoot, Lize C. (author)
- Erasmus University Medical Center
-
- De Jong, Frank Jan (author)
- Erasmus University Medical Center
-
- Donker Kaat, Laura (author)
- Erasmus University Medical Center
-
- Del Campo, Marta (author)
- Vrije Universiteit Amsterdam
-
- Teunissen, Charlotte E. (author)
- Vrije Universiteit Amsterdam
-
- Bron, Esther E. (author)
- Erasmus University Medical Center
-
- Van Den Berg, Esther (author)
- Erasmus University Medical Center
-
- Van Swieten, John C. (author)
- Erasmus University Medical Center
-
show less...
-
(creator_code:org_t)
- 2019-05-23
- 2019
- English 8 s.
-
In: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 90:9, s. 997-1004
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://jnnp.bmj.com...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs=-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs=-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Meeter, Lieke H. ...
-
Steketee, Rebecc ...
-
Salkovic, Dina
-
Vos, Maartje E.
-
Grossman, Murray
-
McMillan, Corey ...
-
show more...
-
Irwin, David J.
-
Boxer, Adam L.
-
Rojas, Julio C.
-
Olney, Nicholas ...
-
Karydas, Anna
-
Miller, Bruce L.
-
Pijnenburg, Yola ...
-
Barkhof, Frederi ...
-
Sánchez-Valle, R ...
-
Lladó, Albert
-
Borrego-Ecija, S ...
-
Diehl-Schmid, Ja ...
-
Grimmer, Timo
-
Goldhardt, Olive ...
-
Santillo, Alexan ...
-
Hansson, Oskar
-
Vestberg, Susann ...
-
Borroni, Barbara
-
Padovani, Alessa ...
-
Galimberti, Dani ...
-
Scarpini, Elio
-
Rohrer, Jonathan ...
-
Woollacott, Ione ...
-
Synofzik, Matthi ...
-
Wilke, Carlo
-
De Mendonca, Ale ...
-
Vandenberghe, Ri ...
-
Benussi, Luisa
-
Ghidoni, Roberta
-
Binetti, Giulian ...
-
Niessen, Wiro J.
-
Papma, Janne M.
-
Seelaar, Harro
-
Jiskoot, Lize C.
-
De Jong, Frank J ...
-
Donker Kaat, Lau ...
-
Del Campo, Marta
-
Teunissen, Charl ...
-
Bron, Esther E.
-
Van Den Berg, Es ...
-
Van Swieten, Joh ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Journal of Neuro ...
- By the university
-
Lund University