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Sökning: WFRF:(Velthut Agne) > Aromatase gene (CYP...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003985naa a2200469 4500
001oai:DiVA.org:uu-107920
003SwePub
008090831s2009 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:118766045
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1079202 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1187660452 URI
0247 a https://doi.org/10.1016/S1472-6483(10)60009-02 DOI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Altmäe, Signeu Karolinska Institutet4 aut
2451 0a Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome :b a preliminary report
264 1c 2009
338 a print2 rdacarrier
520 a Progress has been made towards ascertaining the genetic predictors of ovarian stimulation in IVF. Aromatase cytochrome P450, encoded by the CYP19A1 gene, catalyses a key step in ovarian oestrogen biosynthesis. Hence, the aromatase gene is an attractive candidate for genetic studies. This study aimed to examine the genetic influences of CYP19A1 TCT trinucleotide insertion/deletion (Ins/Del) and (TTTA)(n) microsatellite intronic polymorphisms on ovarian stimulation outcome and aetiology of female infertility. IVF patients (n = 152) underwent ovarian stimulation according to recombinant FSH and gonadotrophin releasing hormone antagonist protocol. Del/Del homozygous patients with shorter TTTA repeats exhibited decreased ovarian FSH sensitivity in ovarian stimulation, which may reflect variations in aromatase gene expression during early antral follicle development. Accordingly, this study demonstrates correlations between Del allele and shorter (TTTA)(n) repeat sizes with smaller ovaries (r = -0.70, P = 0.047) and fewer antral follicles (r = 0.21, P = 0.018) on days 3-5 of spontaneous menstrual cycle, respectively. Furthermore, Del variation linked with low-repeat-number (TTTA)(n) alleles are involved in enhanced genetic susceptibility to unexplained infertility (adjusted OR = 4.33, P = 0.039) and endometriosis (r = -0.88, P = 0.026), which corroborates evidence on the overlapping patient profiles of ovarian dysfunction in both types of female infertility.
653 a aromatase
653 a female infertility
653 a IVF
653 a ovarian stimulation
653 a MEDICINE
653 a MEDICIN
7001 a Haller, Kadriu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut
7001 a Peters, Maireu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut
7001 a Saare, Merliu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut
7001 a Hovatta, Outiu Karolinska Institutet4 aut
7001 a Stavreus-Evers, Anneliu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)annst384
7001 a Velthut, Agneu Nova Vita Clinic, Centre for Infertility Treament and Medical Genetics, Estonia4 aut
7001 a Karro, Helleu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut
7001 a Metspalu, Andresu Dept of Biotechnolgy, Institute of Molecular and Cell Biology, Estonian Genome Foundation, University of Tartu, Estonia4 aut
7001 a Salumets, Andresu Dept of Biotechnolgy, Institute of Molecular and Cell Biology, Estonian Genome Foundation, University of Tartu, Estonia4 aut
7102 a Karolinska Institutetb Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 org
7730 t Reproductive BioMedicine Onlineg 18:5, s. 651-657q 18:5<651-657x 1472-6483x 1472-6491
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107920
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:118766045
8564 8u https://doi.org/10.1016/S1472-6483(10)60009-0

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