Sökning: WFRF:(Venneri Mary Anna) > (2011) > Systemic and Target...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03424naa a2200553 4500 | |
001 | oai:DiVA.org:uu-151911 | |
003 | SwePub | |
008 | 110419s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1519112 URI |
024 | 7 | a https://doi.org/10.1161/ATVBAHA.110.2119202 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Casazza, Andrea4 aut |
245 | 1 0 | a Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models |
264 | 1 | c 2011 |
338 | a print2 rdacarrier | |
520 | a Objective-The role of semaphorins in tumor progression is still poorly understood. In this study, we aimed at elucidating the regulatory role of semaphorin 3A (SEMA3A) in primary tumor growth and metastatic dissemination. Methods and Results-We used 3 different experimental approaches in mouse tumor models: (1) overexpression of SEMA3A in tumor cells, (2) systemic expression of SEMA3A following liver gene transfer in mice, and (3) tumor-targeted release of SEMA3A using gene modified Tie2-expressing monocytes as delivery vehicles. In each of these experimental settings, SEMA3A efficiently inhibited tumor growth by inhibiting vessel function and increasing tumor hypoxia and necrosis, without promoting metastasis. We further show that the expression of the receptor neuropilin-1 in tumor cells is required for SEMA3A-dependent inhibition of tumor cell migration in vitro and metastatic spreading in vivo. Conclusion-In sum, both systemic and tumor-targeted delivery of SEMA3A inhibits tumor angiogenesis and tumor growth in multiple mouse models; moreover, SEMA3A inhibits the metastatic spreading from primary tumors. These data support the rationale for further investigation of SEMA3A as an anticancer molecule. | |
653 | a angiogenesis | |
653 | a molecular biology | |
653 | a pathology | |
653 | a receptors | |
653 | a vascular biology | |
653 | a metastasis | |
653 | a neuropilin | |
653 | a semaphorin | |
653 | a tumor | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Fu, Xiu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut |
700 | 1 | a Johansson, Irjau Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut |
700 | 1 | a Capparuccia, Lorena4 aut |
700 | 1 | a Andersson, Fredriku Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut |
700 | 1 | a Giustacchini, Alice4 aut |
700 | 1 | a Squadrito, Mario Leonardo4 aut |
700 | 1 | a Venneri, Mary Anna4 aut |
700 | 1 | a Mazzone, Massimiliano4 aut |
700 | 1 | a Larsson, Eriku Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)eriklars |
700 | 1 | a Carmeliet, Peter4 aut |
700 | 1 | a De Palma, Michele4 aut |
700 | 1 | a Naldini, Luigi4 aut |
700 | 1 | a Tamagnone, Luca4 aut |
700 | 1 | a Rolny, Charlotteu Uppsala universitet,Cancer och vaskulärbiologi4 aut |
710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
773 | 0 | t Arteriosclerosis, Thrombosis and Vascular Biologyg 31:4, s. 741-749q 31:4<741-749x 1079-5642x 1524-4636 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151911 |
856 | 4 8 | u https://doi.org/10.1161/ATVBAHA.110.211920 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.