Sökning: WFRF:(Vergari Ilaria) > Application of the ...
Fältnamn | Indikatorer | Metadata |
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000 | 04204naa a2200673 4500 | |
001 | oai:gup.ub.gu.se/303594 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:146368508 | |
024 | 7 | a https://gup.ub.gu.se/publication/3035942 URI |
024 | 7 | a https://doi.org/10.1002/alz.122922 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1463685082 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ingala, Silvia4 aut |
245 | 1 0 | a Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort. |
264 | c 2021-04-03 | |
264 | 1 | b Wiley,c 2021 |
520 | a We classified non-demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological and imaging profiles.From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut-offs of 1000 pg/mL for amyloid beta (Aß)1-42 and 27 pg/mL for p-tau181 were validated using Gaussian mixture models. Given strong correlation of p-tau and t-tau (R2 =0.98, P<0.001), neurodegeneration was defined by age-adjusted hippocampal volume. Multinomial regressions were used to test whether neuropsychological tests and regional brain volumes could distinguish ATN stages.Age was 65 ± 7 years, with 58% females and 38% apolipoprotein E (APOE) ε4 carriers; 57.1% were A-T-N-, 32.5% were in the Alzheimer's disease (AD) continuum, and 10.4% suspected non-Alzheimer's pathology. Age and cerebrovascular burden progressed with biomarker positivity (P<0.001). Cognitive dysfunction appeared with T+. Paradoxically higher regional gray matter volumes were observed in A+T-N- compared to A-T-N- (P<0.001).In non-demented individuals along the AD continuum, p-tau drives cognitive dysfunction. Memory and language domains are affected in the earliest stages. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a De Boer, Casper4 aut |
700 | 1 | a Masselink, Larissa A4 aut |
700 | 1 | a Vergari, Ilaria4 aut |
700 | 1 | a Lorenzini, Luigi4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Chételat, Gaël4 aut |
700 | 1 | a Di Perri, Carol4 aut |
700 | 1 | a Ewers, Michael4 aut |
700 | 1 | a van der Flier, Wiesje M4 aut |
700 | 1 | a Fox, Nick C4 aut |
700 | 1 | a Gispert, Juan Domingo4 aut |
700 | 1 | a Haller, Sven4 aut |
700 | 1 | a Molinuevo, José Luís4 aut |
700 | 1 | a Muniz-Terrera, Graciela4 aut |
700 | 1 | a Mutsaerts, Henri Jmm4 aut |
700 | 1 | a Ritchie, Craig W4 aut |
700 | 1 | a Ritchie, Karen4 aut |
700 | 1 | a Schmidt, Mark4 aut |
700 | 1 | a Schwarz, Adam J4 aut |
700 | 1 | a Vermunt, Lisa4 aut |
700 | 1 | a Waldman, Adam D4 aut |
700 | 1 | a Wardlaw, Joanna4 aut |
700 | 1 | a Wink, Alle Meije4 aut |
700 | 1 | a Wolz, Robin4 aut |
700 | 1 | a Wottschel, Viktor4 aut |
700 | 1 | a Scheltens, Philip4 aut |
700 | 1 | a Visser, Pieter Jelleu Karolinska Institutet4 aut |
700 | 1 | a Barkhof, Frederik4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & dementia : the journal of the Alzheimer's Associationd : Wileyg 17:7, s. 1189-1204q 17:7<1189-1204x 1552-5279 |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 17:7, s. 1189-1204q 17:7<1189-1204x 1552-5260 |
856 | 4 | u https://doi.org/10.1002/alz.12292 |
856 | 4 8 | u https://gup.ub.gu.se/publication/303594 |
856 | 4 8 | u https://doi.org/10.1002/alz.12292 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146368508 |
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