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Sökning: WFRF:(Wadsworth Emma J K) > Birth order and chi...

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FältnamnIndikatorerMetadata
00005126naa a2200697 4500
001oai:DiVA.org:liu-67719
003SwePub
008110426s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-677192 URI
0247 a https://doi.org/10.1093/ije/dyq2072 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cardwell, Chris Ru Queens University Belfast4 aut
2451 0a Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies
264 c 2010-12-10
264 1b OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND,c 2011
338 a print2 rdacarrier
520 a Background The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies. Methods Relevant studies published before January 2010 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies provided individual patient data or conducted pre-specified analyses. Meta-analysis techniques were used to derive combined odds ratios (ORs), before and after adjustment for confounders, and investigate heterogeneity. Results Data were available for 6 cohort and 25 case-control studies, including 11 955 cases of type 1 diabetes. Overall, there was no evidence of an association prior to adjustment for confounders. After adjustment for maternal age at birth and other confounders, a reduction in the risk of diabetes in second- or later born children became apparent [fully adjusted OR = 0.90 95% confidence interval (CI) 0.83-0.98; P = 0.02] but this association varied markedly between studies (I-2 = 67%). An a priori subgroup analysis showed that the association was stronger and more consistent in children andlt; 5 years of age (n = 25 studies, maternal age adjusted OR = 0.84 95% CI 0.75, 0.93; I-2 = 23%). Conclusion Although the association varied between studies, there was some evidence of a lower risk of childhood onset type 1 diabetes with increasing birth order, particularly in children aged andlt; 5 years. This finding could reflect increased exposure to infections in early life in later born children.
653 a Diabetes mellitus
653 a type 1
653 a epidemiology
653 a birth order
653 a meta-analysis
653 a MEDICINE
653 a MEDICIN
7001 a Stene, Lars Cu Norwegian Institute Public Health4 aut
7001 a Joner, Geiru University of Oslo4 aut
7001 a Bulsara, Max Ku University of Western Australia4 aut
7001 a Cinek, Ondreju Charles University Prague4 aut
7001 a Rosenbauer, Joachimu University of Dusseldorf4 aut
7001 a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29
7001 a Svensson, Jannetu Glostrup University Hospital4 aut
7001 a Goldacre, Michael Ju University of Oxford4 aut
7001 a Waldhoer, Thomasu Medical University of Vienna4 aut
7001 a Jarosz-Chobot, Przemyslawau Medical University of Silesia4 aut
7001 a Gimeno, Suely G Au University Fed Sao Paulo4 aut
7001 a Chuang, Lee-Mingu National Taiwan University Hospital4 aut
7001 a Roberts, Christine Lu University of Sydney4 aut
7001 a Parslow, Roger Cu University of Leeds4 aut
7001 a Wadsworth, Emma J Ku Cardiff University4 aut
7001 a Chetwynd, Amandau University of Lancaster4 aut
7001 a Brigis, Girtsu Riga Stradins University4 aut
7001 a Urbonaite, Broneu Kaunas University Medical4 aut
7001 a Sipetic, Sandrau University of Belgrade4 aut
7001 a Schober, Edithu Medical University of Vienna4 aut
7001 a Devoti, Gabrieleu University of Lecce4 aut
7001 a Ionescu-Tirgoviste, Constantinu N Paulescu Institute Diabet, Nutr and Metab Disease Clin4 aut
7001 a de Beaufort, Carine Eu Pediat Clin, Luxembourg4 aut
7001 a Stoyanov, Denkau Childrens Diabet Centre, Sofia4 aut
7001 a Buschard, Karstenu Rigshosp, Copenhagen4 aut
7001 a Radon, Katjau Hospital LMU Munich4 aut
7001 a Glatthaar, Christopheru Sir Charles Gairdner Hospital4 aut
7001 a Patterson, Chris Cu Centre for Public Health, Queen’s University Belfast, Belfast, UK4 aut
7102 a Queens University Belfastb Norwegian Institute Public Health4 org
7730 t INTERNATIONAL JOURNAL OF EPIDEMIOLOGYd : OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLANDg 40:2, s. 363-374q 40:2<363-374x 0300-5771x 1464-3685
8564 u https://academic.oup.com/ije/article-pdf/40/2/363/14113020/dyq207.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67719
8564 8u https://doi.org/10.1093/ije/dyq207

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