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High prevalence of ...
High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors.
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Boman, J (author)
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
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Forsberg, J (author)
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Birgander, L S (author)
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Allard, A (author)
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Persson, K (author)
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Jidell, E (author)
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Kumlin, U (author)
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Juto, P (author)
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- Waldenström, Anders (author)
- Umeå universitet,Kardiologi
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Wadell, G (author)
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: Journal of Infectious Diseases. - 0022-1899 .- 1537-6613. ; 178:1
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Nested polymerase chain reaction (nPCR) demonstrated the presence of Chlamydia pneumoniae-specific DNA in peripheral blood mononuclear cells (PBMC). PBMC samples were obtained from 103 consecutive patients (62 male, 41 female) aged 22-85 years (mean, 64) admitted for coronary angiography because of suspected coronary heart disease and from 52 blood donors (43 male, 9 female) aged 40-64 years (mean, 49). Of the 101 evaluable patients, 60 (59%) were identified by nPCR assay as C. pneumoniae DNA carriers; C. pneumoniae-specific microimmunofluorescence (MIF) serology confirmed exposure to the bacterium in 57 (95%) of the 60 nPCR-positive patients. Among the 52 blood donors, the nPCR assay identified 24 (46%) C. pneumoniae DNA carriers, all of whom were positive by C. pneumoniae-specific serology. Thirty-two patients (32%) and 23 blood donors (44%) were MIF antibody-positive but repeatedly nPCR-negative; Bartonella henselae- or Bartonella quintana-specific antibodies were not detected among any of these subjects. In this study, C. pneumoniae DNA was common in PBMC of patients with coronary heart disease and in middle-aged blood donors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Boman, J
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Söderberg, Stefa ...
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Forsberg, J
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Birgander, L S
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Allard, A
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Persson, K
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show more...
-
Jidell, E
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Kumlin, U
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Juto, P
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Waldenström, And ...
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Wadell, G
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Umeå University