Sökning: WFRF:(Wedel H) > (2010-2014) > The impact of coron...
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000 | 04179naa a2200553 4500 | |
001 | oai:gup.ub.gu.se/213652 | |
003 | SwePub | |
008 | 240528s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2136522 URI |
024 | 7 | a https://doi.org/10.1186/s12881-014-0140-32 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Haver, V. G.4 aut |
245 | 1 0 | a The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA) |
264 | c 2014-12-21 | |
264 | 1 | b Springer Science and Business Media LLC,c 2014 |
520 | a Background: Recent genome-wide association studies have identified multiple loci that are associated with an increased risk of developing coronary artery disease (CAD). The impact of these loci on the disease severity and prognosis of ischemic heart failure due to CAD is currently unknown. Methods: We undertook association analysis of 7 single nucleotide polymorphism (rs599839, rs17465637, rs2972147, rs6922269, rs1333049, rs501120, and rs17228212) at 7 well established CAD risk loci (1p13.3, 1q41, 2q36.3, 6q25.1, 9p21.3, 10q11.21, and 15q22.33, respectively) in 3,320 subjects diagnosed with systolic heart failure of ischemic aetiology and participating in the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA) trial. The primary outcome was the composite of time to first event of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke, secondary outcomes included mortality and hospitalization due to worsening heart failure. Results: None of the 7 loci were significantly associated with the primary composite endpoint of the CORONA trial (death from cardiovascular cases, nonfatal myocardial infarction, and nonfatal stroke). However, the 1p13.3 locus (rs599839) showed evidence for association with all-cause mortality (after adjustment for covariates; HR 0.74, 95% CI [0.61 to 0.90]; P = 0.0025) and we confirmed the 1p13.3 locus (rs599839) to be associated with lipid parameters (total cholesterol (P = 1.1x10(-4)), low-density lipoprotein levels (P = 3.5 x 10(-7)) and apolipoprotein B (P = 2.2 x 10(-10))). Conclusion: Genetic variants strongly associated with CAD risk are not associated with the severity and outcome of ischemic heart failure. The observed association of the 1p13.3 locus with all-cause mortality requires confirmation in further studies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Coronary artery disease | |
653 | a Heart failure | |
653 | a Genetics | |
653 | a Healthy ageing | |
653 | a SNP | |
653 | a SUSCEPTIBILITY LOCI | |
653 | a CARDIOMYOPATHY | |
653 | a CHOLESTEROL | |
653 | a DESIGN | |
653 | a 9P21 | |
653 | a Genetics & Heredity | |
700 | 1 | a Verweij, N.4 aut |
700 | 1 | a Kjekshus, J.4 aut |
700 | 1 | a Fox, J. C.4 aut |
700 | 1 | a Wedel, H.4 aut |
700 | 1 | a Wikstrand, John,d 1938u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xwikjo |
700 | 1 | a Van Gilst, W. H.4 aut |
700 | 1 | a de Boer, R. A.4 aut |
700 | 1 | a van Veldhuisen, D. J.4 aut |
700 | 1 | a van der Harst, P.4 aut |
710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
773 | 0 | t Bmc Medical Geneticsd : Springer Science and Business Media LLCg 15:140q 15:140x 1471-2350 |
856 | 4 | u https://bmcmedgenet.biomedcentral.com/track/pdf/10.1186/s12881-014-0140-3 |
856 | 4 8 | u https://gup.ub.gu.se/publication/213652 |
856 | 4 8 | u https://doi.org/10.1186/s12881-014-0140-3 |
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