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Sökning: WFRF:(Wendon J) > (2014) > Aerobic capacity at...

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FältnamnIndikatorerMetadata
00003550naa a2200433 4500
001oai:DiVA.org:uu-210285
003SwePub
008131104s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2102852 URI
0247 a https://doi.org/10.1002/lt.237662 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bernal, William4 aut
2451 0a Aerobic capacity at cardio-pulmonary exercise testing and survival with and without liver transplantation in patients with chronic liver disease
264 c 2013-11-29
264 1b Ovid Technologies (Wolters Kluwer Health),c 2014
338 a print2 rdacarrier
520 a Background: Chronic liver disease (CLD) is associated with muscle wasting, reduced exercise tolerance and aerobic capacity (AC). Measures of AC determined using cardiopulmonary exercise testing (CPET) may predict post liver transplant (LT) survival, but relation to non-transplant outcome is uncertain. In patients assessed for LT we examined the relation of CPET AC parameters to severity of liver disease, nutritional state and survival with and without LT.Patients and Methods:Patients assessed for elective first LT for who underwent CPET and anthropometric assessment at a single centre were studied. CPET-derived measures of AC evaluated were peak oxygen consumption (VO2 -peak) and Anaerobic Threshold (AT).Results:399 patients underwent CPET and 223 LT; 45% of patients had VO2 -peak <50% predicted and 31% AT<9ml/kg/min. VO2 -peak and AT correlated with MELD but more closely with serum sodium and albumin. Hand grip strength correlated strongly with VO2 -peak. Patients with impaired AC had prolonged post-LT hospitalisation and 1-year post-transplantation non-survivors had lower AT than survivors (p<0.05), significant on multivariate analysis. 176 patients did not undergo LT; 1-year mortality was 34.6%. AT (p<0.05) and VO2 -peak (p<0.001) were lower in non-survivors. On multivariate analysis, AT was independently associated with non-survival.Conclusions:Aerobic capacity is markedly impaired in many patients with CLD. In those not transplanted, impaired AT was predictive of mortality and in those undergoing LT related to post-operative hospitalisation and survival. AC should be evaluated as a modifiable factor to improve patient survival, whether or not LT is anticipated.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
7001 a Martin-Mateos, Rosa4 aut
7001 a Lipcsey, Miklósu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)milip123
7001 a Tallis, Caroline4 aut
7001 a Woodsford, Kyne4 aut
7001 a McPhail, Mark J4 aut
7001 a Willars, Christopher4 aut
7001 a Auzinger, Georg4 aut
7001 a Sizer, Elizabeth4 aut
7001 a Heneghan, Michael4 aut
7001 a Cottam, Simon4 aut
7001 a Heaton, Nigel4 aut
7001 a Wendon, Julia4 aut
7102 a Uppsala universitetb Anestesiologi och intensivvård4 org
7730 t Liver transplantationd : Ovid Technologies (Wolters Kluwer Health)g 20:1, s. 54-62q 20:1<54-62x 1527-6465x 1527-6473
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210285
8564 8u https://doi.org/10.1002/lt.23766

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