SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Willander Kerstin 1949 )
 

Sökning: WFRF:(Willander Kerstin 1949 ) > (2005) > Patients with chron...

Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome

Tobin, Gerard (författare)
Thunberg, Ulf (författare)
Laurell, Anna (författare)
visa fler...
Karlsson, Karin (författare)
Åleskog, Anna (författare)
Willander, Kerstin, 1949- (författare)
Linköpings universitet,Hälsouniversitetet,Onkologi
Söderberg, Ola (författare)
Merup, Mats (författare)
Vilpo, Juhani (författare)
Hultdin, Magnus (författare)
Sundström, Christer (författare)
Roos, Göran (författare)
Rosenquist, Richard (författare)
visa färre...
 (creator_code:org_t)
2005
2005
Engelska.
Ingår i: Haematologica. - 0390-6078 .- 1592-8721. ; 90:4, s. 465-469
Relaterad länk:
https://urn.kb.se/re...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background and Objectives. The immunoglobulin VH gene mutation status is a strong prognostic indicator in B-cell chronic lymphocytic leukemia (CLL), since unmutated VH genes are correlated with short survival. However, the traditional cut-off level dividing mutated and unmutated cases, i.e. more or less than 2% mutations, has been questioned and other cut-offs have been suggested. We investigated whether an alternative cut-off should be applied and the relation of mutational status to another prognostic marker, Binet staging. Design and Methods. VH gene mutation status was assessed in 332 CLL cases by polymerase chain reaction amplification and nucleotide sequencing and was further correlated with overall survival using different VH mutation cut-offs (1-7%) and Binet stage. Results. After testing different mutation borders, the 2% cut-off remained the best discriminative level for determining prognosis. Interestingly, prognostic stratification was improved by combining the information on VH gene mutation status with that of Binet stage: unmutated cases (all stages, n=151, mutated cases with stage A (n=77), and mutated cases with stage B or C (n=37) had a median survival of 82, 179 and 74 months, respectively. Interpretation and Conclusions. CLL cases displaying mutated VH genes with Binet stage B or C had a survival similar to that of unmutated cases and significantly shorter than that of mutated stage A CLL. Our result reveals clinical heterogeneity within the VH mutated CLL group by inclusion of Binet stage data, a finding which is of importance when considering surrogate marker(s) for VH mutation status. ©2005 Ferrata Storti Foundation.

Nyckelord

MEDICINE
MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy