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CD161 Defines a Tra...
CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages
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Fergusson, Joannah R. (author)
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Smith, Kira E. (author)
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Fleming, Vicki M. (author)
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Rajoriya, Neil (author)
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Newell, Evan W. (author)
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Simmons, Ruth (author)
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Marchi, Emanuele (author)
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- Björkander, Sophia (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Kang, Yu-Hoi (author)
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Swadling, Leo (author)
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Kurioka, Ayako (author)
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Sahgal, Natasha (author)
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Lockstone, Helen (author)
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Baban, Dilair (author)
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Freeman, Gordon J. (author)
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- Sverremark-Ekström, Eva (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Davis, Mark M. (author)
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Davenport, Miles P. (author)
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Venturi, Vanessa (author)
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Ussher, James E. (author)
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Willberg, Christian B. (author)
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Klenerman, Paul (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 9:3, s. 1075-1088
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https://doi.org/10.1...
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Abstract
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- The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell transcriptional signature enriched in CD161+CD8+ T cells, which can be extended to CD161+ CD4+ and CD161+TCR gamma delta+ T cells. Furthermore, this led to the identification of a shared innate-like, TCR-independent response to interleukin (IL)-12 plus IL-18 by different CD161-expressing T cell populations. This response was independent of regulation by CD161, which acted as a costimulatory molecule in the context of T cell receptor stimulation. Expression of CD161 hence identifies a transcriptional and functional phenotype, shared across human T lymphocytes and independent of both T cell receptor (TCR) expression and cell lineage.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fergusson, Joann ...
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Smith, Kira E.
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Fleming, Vicki M ...
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Rajoriya, Neil
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Newell, Evan W.
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Simmons, Ruth
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show more...
-
Marchi, Emanuele
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Björkander, Soph ...
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Kang, Yu-Hoi
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Swadling, Leo
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Kurioka, Ayako
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Sahgal, Natasha
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Lockstone, Helen
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Baban, Dilair
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Freeman, Gordon ...
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Sverremark-Ekstr ...
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Davis, Mark M.
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Davenport, Miles ...
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Venturi, Vanessa
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Ussher, James E.
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Willberg, Christ ...
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Klenerman, Paul
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Cell Reports
- By the university
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Stockholm University