Sökning: WFRF:(Winchester Laura) > (2020) > Dickkopf-1 Overexpr...
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000 | 09037naa a2201237 4500 | |
001 | oai:gup.ub.gu.se/295674 | |
003 | SwePub | |
008 | 240910s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-85111 | |
009 | oai:prod.swepub.kib.ki.se:145020231 | |
024 | 7 | a https://gup.ub.gu.se/publication/2956742 URI |
024 | 7 | a https://doi.org/10.3233/JAD-2002082 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-851112 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1450202312 URI |
040 | a (SwePub)gud (SwePub)orud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shi, Liuu Department of Psychiatry, University of Oxford, UK4 aut |
245 | 1 0 | a Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. |
264 | 1 | b IOS Press,c 2020 |
500 | a Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF from the European Union's Seventh Framework Programme (FP7/2007-2013) 115372EFPIA companies' European CommissionEuropean Commission Joint Research CentreEuropean Union (EU) QLRT-20012455 37670Stichting voor Alzheimer Onderzoek 11020 13007 15005Swiss National Science Foundation (SNSF) SNF 320030 141179Department of Health of the Basque Government 17.0.1.08.12.0000.2.454.01.41142.001.HUniversity of Antwerp Research Fund NIHR biomedical research centre at UCLH Health Data Research UK National Institute for Health Research (NIHR)Maudsley NHS Foundation Trust King's College London NIHR University College London Hospitals Biomedical Research Centre DPUK through MRC MR/L023784/2Medical Research Council UK (MRC) MC PC 17215NIHR Biomedical Research Centre at Oxford Health NHS Foundation Trust | |
520 | a Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown.We aim to test whether DKK1 induced protein signature obtained in vitro were associated with markers of AD pathology as used in the amyloid/tau/neurodegeneration (ATN) framework as well as with clinical outcomes.We first overexpressed DKK1 in HEK293A cells and quantified 1,128 proteins in cell lysates using aptamer capture arrays (SomaScan) to obtain a protein signature induced by DKK1. We then used the same assay to measure the DKK1-signature proteins in human plasma in two large cohorts, EMIF (n = 785) and ANM (n = 677).We identified a 100-protein signature induced by DKK1 in vitro. Subsets of proteins, along with age and apolipoprotein E ɛ4 genotype distinguished amyloid pathology (A + T-N-, A+T+N-, A+T-N+, and A+T+N+) from no AD pathology (A-T-N-) with an area under the curve of 0.72, 0.81, 0.88, and 0.85, respectively. Furthermore, we found that some signature proteins (e.g., Complement C3 and albumin) were associated with cognitive score and AD diagnosis in both cohorts.Our results add further evidence for a role of DKK regulation of Wnt signaling in AD and suggest that DKK1 induced signature proteins obtained in vitro could reflect theATNframework as well as predict disease severity and progression in vivo. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
653 | a ATN framework | |
700 | 1 | a Winchester, Laura M4 aut |
700 | 1 | a Liu, Benjamine Y4 aut |
700 | 1 | a Killick, Richard4 aut |
700 | 1 | a Ribe, Elena M4 aut |
700 | 1 | a Westwood, Sarah4 aut |
700 | 1 | a Baird, Alison L4 aut |
700 | 1 | a Buckley, Noel J4 aut |
700 | 1 | a Hong, Shengjun4 aut |
700 | 1 | a Dobricic, Valerija4 aut |
700 | 1 | a Kilpert, Fabian4 aut |
700 | 1 | a Franke, Andre4 aut |
700 | 1 | a Kiddle, Steven4 aut |
700 | 1 | a Sattlecker, Martina4 aut |
700 | 1 | a Dobson, Richard4 aut |
700 | 1 | a Cuadrado, Antonio4 aut |
700 | 1 | a Hye, Abdul4 aut |
700 | 1 | a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn |
700 | 1 | a Morgan, Angharad R4 aut |
700 | 1 | a Bos, Isabelle4 aut |
700 | 1 | a Vos, Stephanie J B4 aut |
700 | 1 | a Ten Kate, Mara4 aut |
700 | 1 | a Scheltens, Philip4 aut |
700 | 1 | a Vandenberghe, Rik4 aut |
700 | 1 | a Gabel, Silvy4 aut |
700 | 1 | a Meersmans, Karen4 aut |
700 | 1 | a Engelborghs, Sebastiaan4 aut |
700 | 1 | a De Roeck, Ellen E4 aut |
700 | 1 | a Sleegers, Kristel4 aut |
700 | 1 | a Frisoni, Giovanni B4 aut |
700 | 1 | a Blin, Olivier4 aut |
700 | 1 | a Richardson, Jill C4 aut |
700 | 1 | a Bordet, Régis4 aut |
700 | 1 | a Molinuevo, José L4 aut |
700 | 1 | a Rami, Lorena4 aut |
700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand |
700 | 1 | a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xketpe |
700 | 1 | a Tsolaki, Magda4 aut |
700 | 1 | a Verhey, Frans4 aut |
700 | 1 | a Lleó, Alberto4 aut |
700 | 1 | a Alcolea, Daniel4 aut |
700 | 1 | a Popp, Julius4 aut |
700 | 1 | a Peyratout, Gwendoline4 aut |
700 | 1 | a Martinez-Lage, Pablo4 aut |
700 | 1 | a Tainta, Mikel4 aut |
700 | 1 | a Johannsen, Peter4 aut |
700 | 1 | a Teunissen, Charlotte E4 aut |
700 | 1 | a Freund-Levi, Yvonne,d 1956-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institute, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, UK; Department of Psychiatry, Örebro Universitetssjukhus, Örebro, Sweden4 aut0 (Swepub:oru)yfi |
700 | 1 | a Frölich, Lutz4 aut |
700 | 1 | a Legido-Quigley, Cristina4 aut |
700 | 1 | a Barkhof, Frederik4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Rasmussen, Katrine Laura4 aut |
700 | 1 | a Nordestgaard, Børge Grønne4 aut |
700 | 1 | a Frikke-Schmidt, Ruth4 aut |
700 | 1 | a Nielsen, Sune Fallgaard4 aut |
700 | 1 | a Soininen, Hilkka4 aut |
700 | 1 | a Vellas, Bruno4 aut |
700 | 1 | a Kloszewska, Iwona4 aut |
700 | 1 | a Mecocci, Patrizia4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Morgan, B Paul4 aut |
700 | 1 | a Streffer, Johannes4 aut |
700 | 1 | a Visser, Pieter Jelle4 aut |
700 | 1 | a Bertram, Lars4 aut |
700 | 1 | a Nevado-Holgado, Alejo J4 aut |
700 | 1 | a Lovestone, Simonu Department of Psychiatry, University of Oxford, UK4 aut |
710 | 2 | a Department of Psychiatry, University of Oxford, UKb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Journal of Alzheimer's disease : JADd : IOS Pressg 77:3, s. 1353-1368q 77:3<1353-1368x 1875-8908x 1387-2877 |
856 | 4 | u https://doi.org/10.3233/JAD-200208y Fulltext |
856 | 4 8 | u https://gup.ub.gu.se/publication/295674 |
856 | 4 8 | u https://doi.org/10.3233/JAD-200208 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85111 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145020231 |
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