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Sökning: WFRF:(Wojcik Genevieve L.) > Disentangling Signa...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004675naa a2200757 4500
001oai:DiVA.org:su-204383
003SwePub
008220504s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2043832 URI
0247 a https://doi.org/10.1093/molbev/msac0762 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mendoza-Revilla, Javier4 aut
2451 0a Disentangling Signatures of Selection Before and After European Colonization in Latin Americans 
264 c 2022-04-19
264 1b Oxford University Press (OUP),c 2022
338 a print2 rdacarrier
520 a Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or admixed population. We apply this method to genome-wide SNP data of ∼4,000 individuals in five admixed Latin American cohorts from Brazil, Chile, Colombia, Mexico, and Peru. Our approach replicates previous reports of selection in the human leukocyte antigen region that are consistent with selection post-admixture. We also report novel signals of selection in genomic regions spanning 47 genes, reinforcing many of these signals with an alternative, commonly used local-ancestry-inference approach. These signals include several genes involved in immunity, which may reflect responses to endemic pathogens of the Americas and to the challenge of infectious disease brought by European contact. In addition, some of the strongest signals inferred to be under selection in the Native American ancestral groups of modern Latin Americans overlap with genes implicated in energy metabolism phenotypes, plausibly reflecting adaptations to novel dietary sources available in the Americas. 
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a natural selection
653 a Latin Americans
653 a Native Americans
653 a admixture
7001 a Chacón-Duque, J. Camilou Stockholms universitet,Institutionen för arkeologi och antikens kultur4 aut0 (Swepub:su)cach0137
7001 a Fuentes-Guajardo, Macarena4 aut
7001 a Ormond, Louise4 aut
7001 a Wang, Ke4 aut
7001 a Hurtado, Malena4 aut
7001 a Villegas, Valeria4 aut
7001 a Granja, Vanessa4 aut
7001 a Acuña-Alonzo, Victor4 aut
7001 a Jaramillo, Claudia4 aut
7001 a Arias, William4 aut
7001 a Barquera, Rodrigo4 aut
7001 a Gómez-Valdés, Jorge4 aut
7001 a Villamil-Ramírez, Hugo4 aut
7001 a de Cerqueira, Caio C. Silva4 aut
7001 a Rivera, Keyla M. Badillo4 aut
7001 a Nieves-Colón, Maria A.4 aut
7001 a Gignoux, Christopher R.4 aut
7001 a Wojcik, Genevieve L.4 aut
7001 a Moreno-Estrada, Andrés4 aut
7001 a Hünemeier, Tábita4 aut
7001 a Ramallo, Virginia4 aut
7001 a Schuler-Faccini, Lavinia4 aut
7001 a Gonzalez-José, Rolando4 aut
7001 a Bortolini, Maria-Cátira4 aut
7001 a Canizales-Quinteros, Samuel4 aut
7001 a Gallo, Carla4 aut
7001 a Poletti, Giovanni4 aut
7001 a Bedoya, Gabriel4 aut
7001 a Rothhammer, Francisco4 aut
7001 a Balding, David4 aut
7001 a Fumagalli, Matteo4 aut
7001 a Adhikari, Kaustubh4 aut
7001 a Ruiz-Linares, Andrés4 aut
7001 a Hellenthal, Garrett4 aut
7102 a Stockholms universitetb Institutionen för arkeologi och antikens kultur4 org
7730 t Molecular biology and evolutiond : Oxford University Press (OUP)g 39:4q 39:4x 0737-4038x 1537-1719
8564 u https://doi.org/10.1093/molbev/msac076y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-204383
8564 8u https://doi.org/10.1093/molbev/msac076

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