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Reduced metabolic f...
Reduced metabolic flexibility is a predictor of weight gain among liver transplant recipients
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- Bui, Anh T. (author)
- Virginia Commonwealth Univ VCU, VA USA
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- Chaudhari, Rahul (author)
- VCU, VA USA
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- Bhati, Chandra (author)
- Univ Maryland, MD USA
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- Wolver, Susan (author)
- VCU, VA USA
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- Patel, Samarth (author)
- Lehigh Valley Hosp Cedar Crest, PA USA
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- Boyett, Sherry (author)
- Virginia Commonwealth Univ VCU, VA USA
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- Evans, Marie Claire (author)
- Virginia Commonwealth Univ VCU, VA USA
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- Kamal, Hiba (author)
- Virginia Commonwealth Univ VCU, VA USA
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- Patel, Vaishali (author)
- Virginia Commonwealth Univ VCU, VA USA
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- Forsgren, Mikael (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten
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- Sanyal, Arun J. (author)
- VCU, VA USA
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- Kirkman, Danielle (author)
- VCU, VA USA
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- Siddiqui, Mohammad Shadab (author)
- Virginia Commonwealth Univ VCU, VA USA; West Hosp, VA 23298 USA
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Liver transplantation. - : LIPPINCOTT WILLIAMS & WILKINS. - 1527-6465 .- 1527-6473.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Metabolic flexibility is the ability to match biofuel availability to utilization and is inversely associated with increased metabolic burden among liver transplant (LT) recipients. The present study evaluated the impact of metabolic flexibility on weight gain following LT. LT recipients were enrolled prospectively (n = 47) and followed for 6 months. Metabolic flexibility was measured using whole-room calorimetry and is expressed as a respiratory quotient (RQ). Peak RQ represents maximal carbohydrate metabolism and occurs in the post-prandial state, while trough RQ represents maximal fatty acid metabolism occurring in the fasted state. The clinical, metabolic, and laboratory characteristics of the study cohort of lost weight (n = 14) and gained weight (n = 33) were similar at baseline. Patients who lost weight were more likely to reach maximal RQ (maximal carbohydrate oxidation) early and rapidly transitioned to trough RQ (maximal fatty acid oxidation). In contrast, patients who gained weight had delayed time to peak RQ and trough RQ. In multivariate modeling, time to peak RQ (& beta;-coefficient 0.509, p = 0.01), time from peak RQ to trough RQ (& beta;-coefficient 0.634, p = 0.006), and interaction between time to peak RQ to trough RQ and fasting RQ (& beta;-coefficient 0.447, p = 0.02) directly correlated with the severity of weight gain. No statistically significant relationship between peak RQ, trough RQ, and weight change was demonstrated. Inefficient transition between biofuels (carbohydrates and fatty acids) is associated with weight gain in LT recipients that is independent of clinical metabolic risk. These data offer novel insight into the physiology of obesity after LT with the potential to develop new diagnostics and therapeutics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bui, Anh T.
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Chaudhari, Rahul
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Bhati, Chandra
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Wolver, Susan
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Patel, Samarth
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Boyett, Sherry
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show more...
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Evans, Marie Cla ...
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Kamal, Hiba
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Patel, Vaishali
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Forsgren, Mikael
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Sanyal, Arun J.
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Kirkman, Daniell ...
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Siddiqui, Mohamm ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Liver transplant ...
- By the university
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Linköping University