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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005157naa a2200505 4500
001oai:DiVA.org:uu-329088
003SwePub
008170908s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140544758
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3290882 URI
0247 a https://doi.org/10.1093/cid/cix1362 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1405447582 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Björkman, Andersu Karolinska Institutet4 aut
2451 0a Spatial Distribution of Falciparum Malaria Infections in Zanzibar :b Implications for Focal Drug Administration Strategies Targeting Asymptomatic Parasite Carriers
264 c 2017-04-17
264 1b Oxford University Press (OUP),c 2017
338 a electronic2 rdacarrier
520 a Background: Optimal use of mass/targeted screen-and-treat or mass or focal drug administration as malaria elimination strategies remains unclear. We therefore studied spatial distribution of Plasmodium falciparum infections to compare simulated effects of these strategies on reducing the parasite reservoir in a pre-elimination setting.Methods: P. falciparum rapid diagnostic tests (RDTs) and molecular (polymerase chain reaction [PCR]) and serological (enzyme-linked immunosorbent assay) analyses were performed on finger-prick blood samples from a population-based survey in 3 adjacent communities.Results: Among 5278 persons screened, 13 (0.2%) were positive by RDT and 123 (2.3%) by PCR. PCR-positive individuals were scattered over the study area, but logistic regression analysis suggested a propensity of these infections to cluster around RDT-positive individuals. The odds ratios for being PCR positive was 7.4 (95% confidence interval, 2.8-19.9) for those living in the household of an RDT-positive individual and 1.64 (1.0-2.8; P = .06) for those living within <300 m, compared with >1000 m. Treating everyone within households of RDT-positive individuals (1% population) would target 13% of those who are PCR positive. Treating all living within a radius of <300 or <1000 m (14% or 58% population) would target 30% or 66% of infections, respectively. Among 4431 serologically screened individuals, 26% were seropositive. Treating everyone within seropositive households (63% population) would target 77% of PCR-positive individuals.Conclusions: Presumptive malaria treatment seemed justified within RDT-positive households and potentially worth considering within, for example, a radius of <300 m. Serology was not discriminative enough in identifying ongoing infections for improving focal interventions in this setting but may rather be useful to detect larger transmission foci.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a asymptomatic
653 a falciparum malaria
653 a clustering
7001 a Cook, Jackieu Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17176 Stockholm, Sweden; London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, MRC Trop Epidemiol Grp, London, England4 aut
7001 a Sturrock, Hughu Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA4 aut
7001 a Msellem, Mwinyiu Minist Hlth, Zanzibar Malaria Eliminat Programme, Dar Es Salaam, Tanzania4 aut
7001 a Ali, Abdullahu Minist Hlth, Zanzibar Malaria Eliminat Programme, Dar Es Salaam, Tanzania4 aut
7001 a Xu, Weipingu Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17176 Stockholm, Sweden4 aut
7001 a Molteni, Fabriziou Swiss Trop & Publ Hlth Inst, Dar Es Salaam, Tanzania4 aut
7001 a Gosling, Rolyu Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA4 aut
7001 a Drakeley, Chrisu London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England4 aut
7001 a Mårtensson, Andreas,d 1963-u Uppsala universitet,Internationell barnhälsa och nutrition4 aut0 (Swepub:uu)andma331
7102 a Karolinska Institutetb Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17176 Stockholm, Sweden; London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, MRC Trop Epidemiol Grp, London, England4 org
7730 t Clinical Infectious Diseasesd : Oxford University Press (OUP)g 64:9, s. 1236-1243q 64:9<1236-1243x 1058-4838x 1537-6591
8564 u https://doi.org/10.1093/cid/cix136y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1139586/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://academic.oup.com/cid/article-pdf/64/9/1236/13635215/cix136.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329088
8564 8u https://doi.org/10.1093/cid/cix136
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140544758

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