Sökning: WFRF:(Yu Tingdong) > Genetic variants an...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07280naa a2200613 4500 | |
001 | oai:DiVA.org:kth-246295 | |
003 | SwePub | |
008 | 190325s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2462952 URI |
024 | 7 | a https://doi.org/10.7150/jca.289192 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Huang, Ketuanu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
245 | 1 0 | a Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma |
264 | 1 | b IVYSPRING INT PUBL,c 2019 |
338 | a print2 rdacarrier | |
500 | a QC 20190325 | |
520 | a Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
653 | a hepatocellular carcinoma | |
653 | a cytochrome p450 oxidoreductase | |
653 | a prognosis | |
653 | a hepatitis B virus | |
653 | a hepatectomy | |
700 | 1 | a Liao, Xiwenu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Han, Chuangyeu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Wang, Xiangkunu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Yu, Tingdongu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Yang, Chengkunu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Liu, Xiaoguangu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China.4 aut |
700 | 1 | a Yu, Longu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450000, Henan, Peoples R China.4 aut |
700 | 1 | a Chen, Zhiweiu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Qin, Weiu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Zhu, Guangzhiu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Su, Haou Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Liu, Zhengqianu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Zeng, Xianminu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Zhou, Xinu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Lu, Sicongu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Huang, Jianlvu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Nanning 530031, Guangxi, Peoples R China.4 aut |
700 | 1 | a Liang, Yuu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Liu, Zhengtaou KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ju7n8n |
700 | 1 | a Deng, Jianlongu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 6, Dept Hepatobiliary Surg, Yulin 537000, Guangxi, Peoples R China.4 aut |
700 | 1 | a Ye, Xinpingu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
700 | 1 | a Peng, Taou Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.4 aut |
710 | 2 | a Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.b Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China.4 org |
773 | 0 | t Journal of Cancerd : IVYSPRING INT PUBLg 10:6, s. 1453-1465q 10:6<1453-1465x 1837-9664 |
856 | 4 | u https://www.jcancer.org/v10p1453.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-246295 |
856 | 4 8 | u https://doi.org/10.7150/jca.28919 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy