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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005818naa a2200565 4500
001oai:DiVA.org:uu-497304
003SwePub
008230228s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4973042 URI
0247 a https://doi.org/10.1007/s12020-022-03218-12 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ghosal, Sumanu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
2451 0a Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis
264 c 2022-11-12
264 1b Springer Nature,c 2023
338 a print2 rdacarrier
520 a PurposeTo understand prognostic immune cell infiltration signatures in neuroendocrine neoplasms (NENs), particularly pheochromocytoma and paraganglioma (PCPG), we analyzed tumor transcriptomic data from The Cancer Genome Atlas (TCGA) and other published tumor transcriptomic data of NENs.MethodsWe used CIBERSORT to infer immune cell infiltrations from bulk tumor transcriptomic data from PCPGs, in comparison to gastroenteropancreatic neuroendocrine tumors (GEPNETs) and small cell lung carcinomas (SCLCs). PCPG immune signature was validated with NanoString immune panel in an independent cohort. Unsupervised clustering of the immune infiltration scores from CIBERSORT was used to find immune clusters. A prognostic immune score model for PCPGs and the other NENs were calculated as a linear combination of the estimated infiltration of activated CD8+/CD4+ T cells, activated NK cells, and M0 and M2 macrophages.ResultsIn PCPGs, we found five dominant immune clusters, associated with M2 macrophages, monocytes, activated NK cells, M0 macrophages and regulatory T cells, and CD8+/CD4+ T cells respectively. Non-metastatic tumors were associated with activated NK cells and metastatic tumors were associated with M0 macrophages and regulatory T cells. In GEPNETs and SCLCs, M0 macrophages and regulatory T cells were associated with unfavorable outcomes and features, such as metastasis and high-grade tumors. The prognostic immune score model for PCPGs and the NENs could predict non-aggressive and non-metastatic diseases. In PCPGs, the immune score was also an independent predictor of metastasis-free survival in a multivariate Cox regression analysis.ConclusionThe transcriptomic immune signature in PCPG correlates with clinical features like metastasis and prognosis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Immunologic signature
653 a Pheochromocytoma
653 a Paraganglioma
653 a Metastasis
653 a Biomarkers
7001 a Vanova, Katerina Hadravau Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Uher, Ondreju Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic.4 aut
7001 a Das, Shaoliu NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Patel, Mayanku Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Meuter, Leahu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Huynh, Thanh-Trucu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Jha, Abhisheku Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Talvacchio, Sarau Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Knue, Marianneu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Prodanov, Tamarau Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Zeiger, Martha A.u NCI, Off Surg Scientists Programs, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Nilubol, Narisu NCI, Surg Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Taieb, Davidu Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France.;Aix Marseille Univ, European Ctr Res Med Imaging, Marseille, France.4 aut
7001 a Crona, Joakimu Uppsala universitet,Endokrin tumörbiologi,Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA4 aut0 (Swepub:uu)joacr310
7001 a Shankavaram, Uma T.u NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.4 aut
7001 a Pacak, Karelu Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.4 aut
7102 a Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.b Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic.4 org
7730 t Endocrined : Springer Natureg 79:1, s. 171-179q 79:1<171-179x 1355-008Xx 1559-0100
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497304
8564 8u https://doi.org/10.1007/s12020-022-03218-1

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