Tailorable Membrane-Penetrating Nanoplatform for Highly Efficient Organelle-Specific Localization

Zhang, Xin (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Wang, Chunfei (author): Univ Macau, Peoples R China; Univ Macau, Peoples R China

Feng, Gang (author): Univ Macau, Peoples R China; Univ Macau, Peoples R China

Jiang, Jianxia (author): Linköpings universitet,Tunnfilmsfysik,Tekniska fakulteten

Hu, Jiwen (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Du Rietz, Anna (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Brommesson, Caroline (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Zhang, Xuanjun (author): Univ Macau, Peoples R China; Univ Macau, Peoples R China

Roberg, Karin (author): Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Öron- näsa- och halskliniken

Zhang, Fengling (author): Linköpings universitet,Elektroniska och fotoniska material,Tekniska fakulteten

Shen, Han-Ming (author): Univ Macau, Peoples R China; Univ Macau, Peoples R China

Uvdal, Kajsa (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Hu, Zhang-Jun (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

(creator_code:org_t)

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Abstract Subject headings

Given the breadth of currently arising opportunities and concerns associated with nanoparticles for biomedical imaging, various types of nanoparticles have been widely exploited, especially for cellular/subcellular level probing. However, most currently reported nanoparticles either have inefficient delivery into cells or lack specificity for intracellular destinations. The absence of well-defined nanoplatforms remains a critical challenge hindering practical nano-based bio-imaging. Herein, the authors elaborate on a tailorable membrane-penetrating nanoplatform as a carrier with encapsulated actives and decorated surfaces to tackle the above-mentioned issues. The tunable contents in such a versatile nanoplatform offer huge flexibility to reach the expected properties and functions. Aggregation-induced emission luminogen (AIEgen) is applied to achieve sought-after photophysical properties, specific targeting moieties are installed to give high affinity towards different desired organelles, and critical grafting of cell-penetrating cyclic disulfides (CPCDs) to promote cellular uptake efficiency without sacrificing the specificity. Hereafter, to validate its practicability, the tailored nano products are successfully applied to track the dynamic correlation between mitochondria and lysosomes during autophagy. The authors believe that the strategy and described materials can facilitate the development of functional nanomaterials for various life science applications.

By the author/editor: Zhang, Xin; Wang, Chunfei; Feng, Gang; Jiang, Jianxia; Hu, Jiwen; Du Rietz, Anna; show more...; Brommesson, Caro ...; Zhang, Xuanjun; Ma, Yuguang; Roberg, Karin; Zhang, Fengling; Shen, Han-Ming; Uvdal, Kajsa; Hu, Zhang-Jun; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Other Chemistry ...

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