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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12912naa a2203085 4500 | |
| 001 | oai:lup.lub.lu.se:0ef84e33-6f7f-49b7-b55f-fd7a9629343a | |
| 003 | SwePub | |
| 008 | 160401s2002 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1938628 | |
| 009 | oai:DiVA.org:uu-64977 | |
| 024 | 7 | a https://lup.lub.lu.se/record/3218472 URI |
| 024 | 7 | a https://doi.org/10.1038/sj.bjc.66005962 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19386282 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-649772 URI |
| 040 | a (SwePub)lud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Beral, V4 aut |
| 245 | 1 0 | a Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease |
| 264 | c 2002-11-12 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2002 |
| 520 | a Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1 % per 10 g per day, P < 0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers= 1.03, 95% CI 0.98 - 1.07, and for current smokers=0.99, 0.92 - 1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. (C) 2002 Cancer Research UK. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a collaborative analysis | |
| 653 | a smoking | |
| 653 | a tobacco | |
| 653 | a breast cancer | |
| 653 | a alcohol | |
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| 700 | 1 | a Bergkvist, Lu Uppsala universitet,Centrum för klinisk forskning, Västerås4 aut0 (Swepub:uu)leber451 |
| 700 | 1 | a Magnusson, Cu Karolinska Institutet4 aut |
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| 700 | 1 | a Chang-Claude, J4 aut |
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| 700 | 1 | a Friedman, GD4 aut |
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| 700 | 1 | a Weinstein, AL4 aut |
| 700 | 1 | a Möller, Torgilu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)canc-tmo |
| 700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Ranstam, Jonasu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-jra |
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| 700 | 1 | a Trichopoulos, D4 aut |
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| 700 | 1 | a Folsom, AR4 aut |
| 700 | 1 | a Hulka, BS4 aut |
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| 700 | 1 | a Paganini-Hill, A4 aut |
| 700 | 1 | a Pike, MC4 aut |
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| 700 | 1 | a Alexander, FE4 aut |
| 710 | 2 | a Karolinska Institutetb Centrum för klinisk forskning, Västerås4 org |
| 773 | 0 | t British Journal of Cancerd : Springer Science and Business Media LLCg 87, s. 1234-45q 87:11<1234-1245x 1532-1827x 0007-0920 |
| 773 | 0 | t Br J Cancerd : Springer Science and Business Media LLCg 87, s. 1234-45q 87<1234-45 |
| 856 | 4 | u http://dx.doi.org/10.1038/sj.bjc.6600596y FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/6600596.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/321847 |
| 856 | 4 8 | u https://doi.org/10.1038/sj.bjc.6600596 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938628 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-64977 |
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