Sökning: WFRF:(van Lingen C.) > (2011) > Absolute Quantifica...
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000 | 03984naa a2200445 4500 | |
001 | oai:DiVA.org:uu-189076 | |
003 | SwePub | |
008 | 121223s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1890762 URI |
024 | 7 | a https://doi.org/10.1158/1078-0432.CCR-10-29332 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van der Veldt, Astrid A M4 aut |
245 | 1 0 | a Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography |
264 | 1 | c 2011 |
338 | a print2 rdacarrier | |
520 | a Purpose:Tumor resistance to docetaxel may be associated with reduced drug concentrations in tumor tissue. Positron emission tomography (PET) allows for quantification of radiolabeled docetaxel ([11C]docetaxel) kinetics and might be useful for predicting response to therapy. The primary objective was to evaluate the feasibility of quantitative [11C]docetaxel PET scans in lung cancer patients. The secondary objective was to investigate whether [11C]docetaxel kinetics were associated with tumor perfusion, tumor size, and dexamethasone administration.Experimental Design:Thirty-four lung cancer patients underwent dynamic PET–computed tomography (CT) scans using [11C]docetaxel. Blood flow was measured using oxygen-15 labeled water. The first 24 patients were premedicated with dexamethasone. For quantification of [11C]docetaxel kinetics, the optimal tracer kinetic model was developed and a noninvasive procedure was validated.Results:Reproducible quantification of [11C]docetaxel kinetics in tumors was possible using a noninvasive approach (image derived input function). Thirty-two lesions (size ≥4 cm3) were identified, having a variable net influx rate of [11C]docetaxel (range, 0.0023–0.0229 mL·cm−3·min−1). [11C]docetaxel uptake was highly related to tumor perfusion (Spearman's ρ = 0.815;P < 0.001), but not to tumor size (Spearman's ρ = −0.140; P = 0.446). Patients pretreated with dexamethasone showed lower [11C]docetaxel uptake in tumors (P = 0.013). Finally, in a subgroup of patients who subsequently received docetaxel therapy, relative high [11C]docetaxel uptake was related with improved tumor response.Conclusions:Quantification of [11C]docetaxel kinetics in lung cancer was feasible in a clinical setting. Variable [11C]docetaxel kinetics in tumors may reflect differential sensitivity to docetaxel therapy. Our findings warrant further studies investigating the predictive value of [11C]docetaxel uptake and the effects of comedication on [11C]docetaxel kinetics in tumors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
700 | 1 | a Lubberink, Marku Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands4 aut0 (Swepub:uu)marklubb |
700 | 1 | a Greuter, Henri N4 aut |
700 | 1 | a Comans, Emile F I4 aut |
700 | 1 | a Herder, Gerarda J M4 aut |
700 | 1 | a Yaqub, Maqsood4 aut |
700 | 1 | a Schuit, Robert C4 aut |
700 | 1 | a van Lingen, Arthur4 aut |
700 | 1 | a Rizvi, S Nafees4 aut |
700 | 1 | a Mooijer, Martien P J4 aut |
700 | 1 | a Rijnders, Anneloes Y4 aut |
700 | 1 | a Windhorst, Albert D4 aut |
700 | 1 | a Smit, Egbert F4 aut |
700 | 1 | a Hendrikse, N Harry4 aut |
700 | 1 | a Lammertsma, Adriaan A4 aut |
710 | 2 | a Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands4 org |
773 | 0 | t Clinical Cancer Researchg 17:14, s. 4814-4824q 17:14<4814-4824x 1078-0432x 1557-3265 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189076 |
856 | 4 8 | u https://doi.org/10.1158/1078-0432.CCR-10-2933 |
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