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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004585naa a2200505 4500
001oai:DiVA.org:uu-462602
003SwePub
008211228s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:148667626
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4626022 URI
0247 a https://doi.org/10.1053/j.gastro.2021.10.0032 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486676262 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Holmberg, Dagu Karolinska Institutet4 aut
2451 0a Incidence and Mortality in Upper Gastrointestinal Cancer After Negative Endoscopy for Gastroesophageal Reflux Disease
264 1b Elsevier BV,c 2022
338 a electronic2 rdacarrier
520 a BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with decreased incidence and mortality in upper gastrointestinal cancer (ie, esophageal, gastric, or duodenal cancer).METHODS: We conducted a population-based cohort study of all patients with newly diagnosed GERD between July 1, 1979 and December 31, 2018 in Denmark, Finland, Norway, and Sweden. The exposure, negative upper endoscopy, was examined as a time-varying exposure, where participants contributed unexposed person-time from GERD diagnosis until screened and exposed person-time from the negative upper endoscopy. The incidence and mortality in upper gastrointestinal cancer were assessed using parametric flexible models, providing adjusted hazard ratios (HRs) with 95% confidence intervals (CIs).RESULTS: Among 1,062,740 patients with GERD (median age 58 years; 52% were women) followed for a mean of 7.0 person-years, 5324 (0.5%) developed upper gastrointestinal cancer and 4465 (0.4%) died from such cancer. Patients who had a negative upper endoscopy had a 55% decreased risk of upper gastrointestinal cancer compared with those who did not undergo endoscopy (HR, 0.45; 95% CI, 0.43-0.48), a decrease that was more pronounced during more recent years (HR, 0.34; 95% CI, 0.30-0.38 from 2008 onward), and was otherwise stable across sex and age groups. The corresponding reduction in upper gastrointestinal mortality among patients with upper endoscopy was 61% (adjusted HR, 0.39; 95% CI, 0.37-0.42). The risk reduction after a negative upper endoscopy in incidence and mortality lasted for 5 and at least 10 years, respectively.CONCLUSIONS: Negative upper endoscopy is associated with strong and long-lasting decreases in incidence and mortality in upper gastrointestinal cancer in patients with GERD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Esophageal Neoplasm
653 a Gastric Neoplasm
653 a Gastroesophageal Reflux Disease
653 a Gastroscopy
7001 a Santoni, Giolau Karolinska Institutet4 aut
7001 a von Euler-Chelpin, My Catarina4 aut
7001 a Färkkilä, Martti4 aut
7001 a Kauppila, Joonas Hu Karolinska Institutet4 aut
7001 a Maret-Ouda, Johnu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut
7001 a Ness-Jensen, Eivindu Karolinska Institutet4 aut
7001 a Lagergren, Jesperu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Centrum för klinisk forskning i Sörmland (CKFD)4 org
7730 t Gastroenterologyd : Elsevier BVg 162:2, s. 431-438.e4q 162:2<431-438.e4x 0016-5085x 1528-0012
8564 u https://doi.org/10.1053/j.gastro.2021.10.003y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1623133/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.gastrojournal.org/article/S0016508521036179/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462602
8564 8u https://doi.org/10.1053/j.gastro.2021.10.003
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148667626

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