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Inheritance beyond ...
Inheritance beyond plain heritability : variance-controlling genes in Arabidopsis thaliana
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- Shen, Xia (författare)
- Uppsala universitet,Högskolan Dalarna,Statistik,Institutionen för cell- och molekylärbiologi
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- Pettersson, Mats (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Rönnegård, Lars (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Högskolan Dalarna,Statistik,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Carlborg, Örjan (författare)
- Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för cell- och molekylärbiologi,Swedish University of Agricultural Sciences, Uppsala, Sweden,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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(creator_code:org_t)
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- 2012-08-02
- 2012
- Engelska.
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 8:8
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Abstract
Ämnesord
Stäng
- The phenotypic effect of a gene is normally described by the mean-difference between alternative genotypes. A gene may, however, also influence the phenotype by causing a difference in variance between genotypes. Here, we reanalyze a publicly available Arabidopsis thaliana dataset [1] and show that genetic variance heterogeneity appears to be as common as normal additive effects on a genomewide scale. The study also develops theory to estimate the contributions of variance differences between genotypes to the phenotypic variance, and this is used to show that individual loci can explain more than 20% of the phenotypic variance. Two well-studied systems, cellular control of molybdenum level by the ion-transporter MOT1 and flowering-time regulation by the FRI-FLC expression network, and a novel association for Leaf serration are used to illustrate the contribution of major individual loci, expression pathways, and gene-by-environment interactions to the genetic variance heterogeneity.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Nyckelord
- Statistisk modellering är grunden till en ökad förståelse inom genetik!
- General Microdata Analysis - methods
- Allmänt Mikrodataaanalys - metod
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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