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Nitric oxide-depend...
Nitric oxide-dependent mitotic activity in salivary glands of the rat upon sympathetic stimulation
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- Ekström, Jörgen (författare)
- Department of Pharmacology, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
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- Sayardoust, Shariel (författare)
- Department of Pharmacology, Sahlgrenska Academy Göteborg University, Göteborg, Sweden
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Çevik, Hülya (författare)
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(creator_code:org_t)
- Elsevier, 2004
- 2004
- Engelska.
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Ingår i: Archives of Oral Biology. - : Elsevier. - 0003-9969 .- 1879-1506. ; 49:11, s. 889-894
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Incorporation of [3H]thymidine into trichloroacetic acid (TCA)-insoluble material of the parotid and submandibular glands was used as an index of mitotic activity following unilateral electrical stimulation of the sympathetic innervation (20 Hz, 4 min every fifth minute over 34 min). Stimulation under β-adrenoceptor blockade (propranolol 2 mg/kg, intravenous) alone or combined with α-adrenoceptor blockade (phentolamine 2 mg/kg, intravenous) did not increase the rate of [3H]thymidine incorporation into the two types of glands. However, under α-adrenoceptor blockade the [3H]thymidine incorporation increased into the parotid glands, by 122% (compared to the glands on the contralateral side), but not into the submandibular glands. In the presence of the neuronal type NO-synthase (nNOS) blocker N-PLA (30 mg/kg, intravenous) or the unselective NO-synthase blocker L-NAME (30 mg/kg, intravenous), this increase was reduced to 49 and 47%, respectively. Thus, the major part of the sympathetically nerve-evoked β-adrenoceptor-mediated mitotic response was found to depend on the activity of neuronal type NO-synthase to generate NO. Since the sympathetic nerve fibres of the parotid gland lack NO-synthase, the neuronal type NO-synthase subjected to the inhibitors is likely to be of parenchymal origin. © 2004 Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- β-Adrenoceptors
- Mitosis
- Nitric oxide synthase
- Salivary glands
- Sympathetic nerve stimulation
- alpha adrenergic receptor blocking agent
- beta adrenergic receptor blocking agent
- nitric oxide
- phentolamine
- propranolol
- adrenergic system
- animal
- article
- cytology
- drug effect
- electrostimulation
- female
- innervation
- parotid gland
- physiology
- rat
- salivary gland
- Sprague Dawley rat
- submandibular gland
- Adrenergic alpha-Antagonists
- Adrenergic beta-Antagonists
- Animals
- Electric Stimulation
- Rats
- Rats
- Sprague-Dawley
- Sympathetic Nervous System
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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